Vertex Pharmaceuticals, Inc.

The Rockefeller University

Memorial Sloan Kettering Cancer Center

Bryce W Carey

Christopher D Thanos

Craig B Thompson

George Harb

C David Allis

Chunhui Xie

Suyash Raj

Evrett Thompson

Rebecca Chinn

Aleksander Szymaniak

Lydia WS Finley

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

Stem cell derived pancreatic islet differentiation

Growing community of inventors

Boston, MA, United States of America

Bryce W Carey