Vanderbilt University

Southern Illinois University

University of California

Bryce E Kidd

Boyd M Goodson

Eduard Y Chekmenev

Roman V Shchepin

Fan Shi

Yuqing Hou

Danila A Barskiy

Max E Gemeinhardt

Miranda Limbach

Igor V Koptyug

Jamil A Mashni

Kirill V Kovtunov

Jonathan Gesiorski

The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

Cleavable agents

The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.

Removal of homogeneous catalysts from NMR/MRI agents hyperpolarized via sabre or PHIP

Growing community of inventors

Carbondale, IL, United States of America

Bryce E Kidd