Morphic Therapeutic, Inc.

Axovant Sciences Gmbh

Denali Therapeutics Inc.

Bryce Alden Harrison

Matthew Gregory Bursavich

Bruce Nelsen Rogers

Aleksey I Gerasyuto

Blaise S Lippa

Dawn M Troast

Fu-Yang Lin

Kyle D Konze

Kristopher N Hahn

Mats A Svensson

Alexey Alexandrovich Lugovskoy

Cheng Zhong

Byungchan Kim

Tyler Day

Brian Sosa

James E Dowling

Eugene R Hickey

Duane A Burnett

Andrew Cook

Andrew J McRiner

Raksha A Acharya

Andrea Bortolato

Mark Brewer

Qi Qiao

Robert Zahler

Ross Mabon

David Brent Rawlins

Dennis Stewart Rice

Salma Rafi

Dan Cui

Evelyne Houang

Nicole Cathleen Goodwin

Spencer David Kimball

Gerhard Koenig

Jason Patrick Healy

Norris Andrew Whitlock

Michael Victor Voronkov

Andrew Simon Cook

Ying Liu

Hugh Alfred Burgoon

Yulian Zhang

Angrea Bortolato

Brett Marinelli

Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of diseases and conditions. The small molecule inhibitors of αvβ6 integrin have a tetrahydroquinoline moiety linked by a -alkylene-CH(F)—, -alkylene-C(F)—, -alkylene-CH(F)CH—, -alkylene-C(F)2CH—, -alkylene-O-alkylene-CH(F)—, or -alkylene-O-alkylene-C(F)— to a pyrrolidine moiety.

Inhibitors of αvβ6 integrin

Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of diseases and conditions.

Inhibiting (α-v)(β-6) integrin

Inhibitors of (αv)(β6) integrin

Disclosed are small molecule antagonists of α4β7 integrin, and methods of using them to treat a number of specific diseases or conditions.

Antagonists of human integrin α4β7

Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of specific diseases or conditions.

Inhibitors of (α-v)(β-6) integrin

Disclosed are small molecule inhibitors of &#x3b1;v&#x3b2;6 integrin, and methods of using them to treat a number of diseases and conditions.

Inhibitors of (&#x3b1;-v)(&#x3b2;-6) integrin

Disclosed are small molecule inhibitors of &#x3b1;v&#x3b2;6 integrin, and methods of using them to treat a number of specific diseases or conditions.

Inhibiting (&#x3b1;-v)(&#x3b2;-6) integrin

Disclosed are small molecule antagonists of human &#x3b1;&#x3b2;integrin, and methods of using them to treat a number of diseases and conditions.

Inhibiting human integrin (alpha-4) (beta-7)

Disclosed are small molecule antagonists of &#x3b1;4&#x3b2;7 integrin, and methods of using them to treat a number of specific diseases or conditions.

Antagonists of human integrin (&#x3b1;4)(&#x3b2;7)

Inhibiting human integrin (&#x3b1;-4) (&#x3b2;-7)

Inhibitors of (alpha-v)(beta-6) integrin

Inhibiting (&#x3b1;-V)(&#x3b2;-6) integrin

Growing community of inventors

Framingham, MA, United States of America

Bryce Alden Harrison