Medtronic, Inc.

Mozarc Medical US LLC

Bryant J Pudil

Martin T Gerber

Thomas Edward Meyer

David B Lura

Suping Lyu

Christopher M Hobot

Brian Mullins

John E Burnes

VenKatesh R Manda

Thomas D Kelly

Keith Robert Hildebrand

Michael Eric Benz

Mark Fredrick Daniels

Kenneth J Collier

Manda R VenKatesh

Kanjimpuredathil Muralikrishna Menon

Sukalyan Dutta

Orhan Soykan

Carl A Schu

Ramkumar Jeyachandran

Kaustubh R Patil

Linda L Ruetz

Eric A Grovender

Krishnaraja Nellikunje

Soykan Orhan

Manda R VenKalesh

Gokul Prabhu Loganathan

Mariangela Iatalese

Mark David Schneider

Michael J Elvidge

Michael JM Mazack

Gokul L Prabhu

Mark F Daniels

Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer. The systems and methods generate a pH-modifying fluid and selectively add the pH modifying fluid to the dialysate in order to accurately control the total bicarbonate buffer concentration in the dialysate entering the dialyzer.

PH and buffer management system for hemodialysis systems

The invention relates to devices, systems, and methods for calculating a bicarbonate concentration in a fluid used in dialysis. The devices, systems, and methods can be used to calculate the bicarbonate concentration in either dialysate or blood. The invention measures the amount of carbon dioxide in both an acidified and non-acidified solution and calculates the bicarbonate concentration based on the difference in carbon dioxide concentrations.

Bicarbonate sensor for dialysis

Sorbent cartridges having a flow control insert to improve the functional capacity of a sorbent cartridge is provided. Flow control inserts can include a plurality of flow channels filled with sorbent material through which fluid to be regenerated can travel in the sorbent cartridge.

Sorbent cartridge designs

The invention relates to devices, systems, and methods for preforming a precision dialysis therapy session based on an analysis of an effluent from a zirconium phosphate sorbent module during an ammonium removal process. The settings for the precision dialysis therapy session can be obtained by estimating a patient's physiological state, such as BUN level, based on the analysis of the effluent for a particular sorbent module linked to a particular patient.

Precision dialysis therapy based on sorbent effluent analysis

A system for measuring at least one fluid characteristic at various stages within a sorbent system that has a sorbent cartridge that has at least one material layer and at least one fluid passageway in at least one location in the sorbent system to provide a diverted sample stream from the various stages. At least one fluid characteristic of the diverted sample stream is measured.

Fluid circuits for sorbent cartridges with sensors

The disclosure relates to systems and methods for controlling the sodium and bicarbonate concentrations in a dialysate. The systems and methods can use conductivity sensors to control the addition of water and bicarbonate to accurately control the final concentrations of both sodium and bicarbonate.

Sodium and bicarbonate control

The invention relates to systems and methods for disinfecting, recharging, and conditioning zirconium phosphate in a reusable sorbent module. The systems and methods provide for reuse of a zirconium phosphate sorbent module after dialysis.

Zirconium phosphate disinfection recharging and conditioning

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

Recirculating dialysate fluid circuit for measurement of blood solute species

A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session.

Fluid circuit for delivery of renal replacement therapies

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

Adaptive system for blood fluid removal

The invention relates to devices, systems, and methods for conditioning a zirconium oxide sorbent module for use in dialysis after recharging. The devices, systems, and methods can provide for conditioning and recharging of zirconium oxide in a single system, or in separate systems.

Zirconium oxide module conditioning

The invention relates to devices, systems, and methods for precision recharging of sorbent materials in a sorbent module. The devices, systems, and methods use manufacturing characteristics of the sorbent module to set recharge parameters used in recharging the sorbent material.

Precision recharging based on sorbent module manufacturing characteristics

A sorbent cartridge that has at least one sensor located within the sorbent cartridge.

Sorbent cartridge with electrodes

The invention relates to devices, systems, and methods for recharging zirconium phosphate and/or zirconium oxide in reusable sorbent modules. The devices, systems, and methods provide for precision recharging of the zirconium phosphate and/or zirconium oxide to avoid the need of excess recharge solutions. The devices systems and methods also provide for calculation of the volumes of recharge solution needed for fully recharging the zirconium phosphate and zirconium oxide modules.

System for precision recharging of sorbent materials using patient and session data

The invention relates to devices, systems, and methods for mixing one or more solutions to generate a recharge solution having specified concentrations of a sodium salt and acid for recharging and disinfecting zirconium phosphate in reusable sorbent modules. The devices, systems, and methods can generate a recharge solution by a sorbent recharger that is introduced through the sorbent module to recharge and to disinfect the zirconium phosphate.

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Plymouth, MN, United States of America

Bryant J Pudil