Pulmonox Technologies Corporation

Advanced Inhalation Therapies (ait), Ltd.

Anoxa Corp.

Bryan Perry

Christopher C Miller

Douglas R Hole

Bruce R Murray

Robert E Lee

Stephen H Fairbanks

Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.

Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant

The use of type V phosphodiesterase inhibitors as a novel independent therapeutic modality in the treatment of exercise induced pulmonary hemorrhage in equine is described. The type V phosphodiesterase inhibitor is injected into the horse intravenously as a stand-alone agent from about one-half hour to about seven (7) days prior to the onset of strenuous exercise.

Use of type V phosphodiesterase inhibitors in the treatment of exercise induced pulmonary hemorrhage in the equine

The present invention is directed to a nitric gas dispenser for mammals on the run. The dispenser has a housing that contains a valve mechanism. The valve mechanism is interconnected between a nitric gas dispersal component that provides nitric gas at a desired pressure and a gas delivery system that provides the nitric gas at the desired pressure to the mammal. The valve mechanism controls the flow of the nitric gas between the nitric gas dispersal component and the gas delivery system. The dispenser also has a pressure sensor that is positioned along the gas delivery system and determines when the mammal is taking a breadth. If the pressure sensor determines the mammal is taking a breadth, the pressure sensor transmits a breadth signal to a microprocessor. The microprocessor then determines if the mammal is within a prescribed time frame for the mammal to be administered nitric gas. If the microprocessor determine the mammal is within the prescribed time frame, the microprocessor transmits an open signal to the valve mechanism to release a predetermined amount of nitric oxide gas to the mammal.

Device for administration of nitric oxide to horses spontaneously breathing

Growing community of inventors

West Seneca, NY, United States of America

Bryan Perry