Glimmerglass Networks, Inc.

Complete Genomics, Inc.

Apton Biosystems, Inc.

Silicon Light Machines Corporation

Pacific Biosciences of California, Inc.

Complete Genomincs, Inc.

Bryan P Staker

Niandong Liu

Windsor Owens

Craig E Uhrich

Andres Fernandez

Manohar R Furtado

Michael David McLaughlin

Norman Burns

Bart Lee Staker

Douglas L Teeter

Lawrence Muray

Rixun N Fang

Paul Heilman

David Thomas Amm

Edvinas Zizminskas

David M Bloom

James A Hunter

David Stern

James Spallas

David A LeHoty

Eric L Bogatin

Eugene W Campbell

Robert Hartlage

Radoje Drmanac

David T Amm

Ralph G Whitten

Akira Tomita

William Banyai

Paul H Pax

Michael J Daneman

Bryan E Loucks

William C Banyai

Alexander P Kindwall

Jonathan G Bornstein

Dennis Ballinger

Rixun Fang

Jim Jahncke

Rob Hartlage

Thomas A DeBey

Michael David Mclauglin

Windsor E Owens

Michael David Mclaughlin

Disclosed herein is a high throughput optical scanning system to generate super resolution images and methods of use. The optical scanning device and methods of use provided herein can allow high throughput scanning of a continuously moving object with a high resolution despite fluctuations in stage velocity. This can aid in high throughput scanning of a substrate, such as a biological chip comprising fluorophores. Also provided herein are improved optical relay systems and scanning optics.

High speed scanning systems for super resolution imaging

Disclosed herein is a high throughput optical scanning device and methods of use. The optical scanning device and methods of use provided herein can allow high throughput scanning of a continuously moving object with a high resolution despite fluctuations in stage velocity. This can aid in high throughput scanning of a substrate, such as a biological chip comprising fluorophores. Also provided herein are improved optical relay systems and scanning optics.

High speed scanning system with acceleration tracking

Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Methods of analyte detection

Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. There have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy or polynucleotide sequencing applications.

Sequencing and high resolution imaging

Densley-packed analyte layers and detection methods

Methods are provided for detecting a single compound analyte immobilized to a solid substrate by serially contacting and removing different probes to the same analyte.

Methods for single molecule analyte detection

Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

Digital analysis of molecular analytes using electrical methods

Processing high density analyte arrays

Growing community of inventors

Palo Alto, CA, United States of America

Bryan P Staker