Wisconsin Alumni Research Foundation

Ge Precision Healthcare LLC

Bryan P Bednarz

Jamey Paul Weichert

Mario Otto

Anatoly Pinchuk

Paul M Sondel

Zachary Scott Morris

Peter Carlson

Dana C Baiu

Lowell Scott Smith

Thomas Kwok-Fah Foo

David Martin Mills

Warren Lee

Jhimli Mitra

Bo Wang

Roberta Marie Strigel

James Hartman Holmes

Jamie Weichert

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris —N(CH). The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, Rincludes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radioactive iodine isotope.

Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors

A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein Ris a radioactive halogen isotope, n is 18 and Ris —N(CH).

Radiohalogenated agents for in situ immune modulated cancer vaccination

The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula: wherein Rcomprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and Ris &#x2014;N(CH).

Targeted radiotherapy chelates for in situ immune modulated cancer vaccination

It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris &#x2014;N(CH). The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, Rincludes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radioactive iodine isotope.

A system and method for providing virtual real-time MRI-guidance for a biopsy outside of a conventional MRI scanner is described. MR images and ultrasound images of a region of a patient's body are simultaneously acquired during a pre-biopsy procedure. Respiratory states that the patient may experience during the biopsy are then determined from the acquired ultrasound images, and each respiratory state is associated with corresponding MR images. The MR images are indexed with their corresponding respiratory state. Ultrasound images are then acquired of the patient during a biopsy procedure. The respiratory state of the patient is determined from the ultrasound images, and the corresponding indexed MR images are displayed.

Image-guided biopsy techniques

A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein Ris a radioactive halogen isotope, n isand Ris &#x2014;N(CH).

Growing community of inventors

Madison, WI, United States of America

Bryan P Bednarz