American Cyanamid Company

Bryan M O'Hara

Stephen V Johann

Marja Van Zeijl

George A Ellestad

Paul Wai Mak

Antonina A Nikitenko

Yakov Gluzman, Deceased

Boris Mitsner

John E Morin

James P LaRocque

Yuri E Raifeld

Wei-Dong Ding

Methods of screening for modulators of respiratory syncytial virus matrix protein interaction are described. A host cell carrying a nucleic acid sequence encoding RSV matrix protein or fragments of RSV matrix protein which can bind to RSV matrix protein is cultured and the RSV matrix protein or RSV fragments are expressed. The interaction of the expressed RSV matrix protein or fragments is measured. A test sample is then added to the expressed RSV matrix protein or fragments and the effect of the test sample on RSV matrix protein interaction is measured.

Methods of screening for modulators of respiratory syncytial virus

The present invention relates to novel purified gibbon ape leukemia receptor proteins and purified DNA sequences encoding these receptor proteins.

Gibbon ape leukemia virus receptor

This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.

Triazine containing anionic compounds useful as antiviral agents

The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding for Gibbon Ape Leukemia Virus (GALV). Differences for the type of retroviruses interacting with the receptors exist. The protein encoding by the GLVR2 gene, cells transformed or transfected by the gene and vectors containing the gene are also disclosed.

Amphotropic virus receptor

The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding Gibbon Ape Leukemia Virus (GALV) receptor. Differences in the type of retroviruses interacting with the receptors exist. The protein encoded by the GLVR2, cells transformed or transfected by the gene, and vectors containing the gene are also disclosed.

Nucleic acid molecule encoding the amphotropic virus receptor

The present invention relates to the gibbon ape leukemia virus (GALV) receptor protein and gene, as well as methods for regulating viral entry into cells.

DNA encoding gibbon ape leukemia virus receptor

The present invention relates to novel purified gibbon ape leukemia receptor proteins and purified DNA sequences encoding these receptor proteins. The invention also relates to a method for identifying receptor proteins using the isolated DNA sequence as a probe, and a method for regulating viral entry into cells by manipulation of the GALV receptor.

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Pearl River, NY, United States of America

Bryan M O'Hara