US Government as Represented by the Secretary of the Army

60 Degrees Pharmaceuticals, LLC

Amivas, Inc.

Other

Bryan L Smith

John P Jones

Budda Balasubrahmanyam

Moshe Shmuklarsky

Geoffrey Stuart Dow

Lisa Thomas Read

Anthony C Lupo

Balasubrahmanyam Budda

Geoffrey S Dow

Disclosed herein are powders including a therapeutically effective amount of 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.00]1exadecane-10-yl]oxy]butanoic acid (artesunate) or a pharmaceutically acceptable salt thereof that can be easily manufactured, sterilized and packaged. Processes for producing these powders and pharmaceutical compositions containing these powders are also disclosed.

Artesunate powders, pharmaceutical compositions and methods of manufacture

Methods of prevention of symptomatic malaria in a malaria-na&#xef;ve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of, during potential exposure of a species of, and after potential exposure of a species of. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-na&#xef;ve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-na&#xef;ve, G6PD-normal subjects.

Regimens of tafenoquine for prevention of malaria in malaria-na&#xef;ve subjects

Methods of prevention of symptomatic malaria in a malaria-na&#xef;ve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of, during potential exposure of a species of, and after potential exposure of a species of. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-na&#xef;ve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-na&#xef;ve, G6PD-normal subjects. 

Regimens of tafenoquine for prevention of malaria in malaria-naive subjects

A multiple-use bunk bed has a top bunk ( ) and a trundle bunk ( ) positioned intermediate a first bedstead ( ) and a second bedstead ( ). The trundle bunk includes casters ( ) on which the trundle bunk is adapted to be positioned intermediate a bottom of the first bedstead and a bottom of the second bedstead in a non-use mode and to be rolled out from between them for a use mode that includes use for sleeping. Vertically above the trundle bunk and under the top bunk intermediate the bedsteads are a desktop ( ), shelves ( ) and drawers ( ). A closet ( ) with a closet door ( ) is positioned intermediate a back of the bunk bed and a closet wall ( ) at an inside of the desktop. The drawers can include left-side drawers, right-side drawers, central drawers and bottom drawers. The multiple-use bunk bed can include single, regular, queen, king and special sizes. Size adaptations are made with positioning of support beams ( ) for bottom-support embodiments and with width of hanging-support walls ( ) for hanging-support embodiments.

Multiple use bunk bed

Growing community of inventors

Chevy Chase, MD, United States of America

Bryan L Smith