Sirenas LLC

Bryan Junn Lee

Steven Bruce Cohen

Jacob Neal Beverage

Ippei Usui

Venkat Rami Reddy Macherla

Eduardo Esquenazi

Alexander Wayne Schammel

Chung-Mao Pan

Elizabeth Paige Stout

Farhana Barmare

Venkata Rami Reddy Macherla

Oliver Booth Vining

Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

Cyclic peptide analogs and conjugates thereof

Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

Anti-cancer compounds and conjugates thereof

Growing community of inventors

San Diego, CA, United States of America

Bryan Junn Lee