Sintx Technologies, Inc.

Amedica Corporation

The United States of America As Represented by the United States

Bryan J McEntire

Ryan M Bock

Bhajanjit Singh Bal

Ramaswamy Lakshminarayanan

Giuseppe Pezzotti

Nicholas Grimaldi

Kevin Davis

Anil Vasudeo Virkar

Prabhakar Thirugnanasambandam

Giuseppe Pezotti

Disclosed herein are methods for laser cladding a coating the surface of a biomedical implant. The biomedical implant may be an implant with a laser-cladded silicon nitride coating for promoting osteogenesis.

Methods of silicon nitride laser cladding

Disclosed herein are methods for functionalizing the surface of a biomedical implant. The biomedical implant may be a zirconia-toughened alumina implant surface functionalized with silicon nitride powder for promoting osteogenesis.

Methods of surface functionalization of zirconia-toughened alumina with silicon nitride

Methods for improving the wear performance of silicon nitride and/or other ceramic materials, particularly to make them more suitable for use in manufacturing biomedical implants.

Method for improving the wear performance of ceramic-polyethylene or ceramic-ceramic articulation couples utilized in orthopedic joint prostheses

Disclosed herein are compositions, devices and methods for inactivating viruses, bacteria, and fungi. The compositions, methods, and devices may include coatings or slurries such as silicon nitride powder coatings or slurries for the inactivation of viruses, bacteria, and/or fungi.

Antipathogenic devices and methods thereof

Described herein is an antiviral face mask and methods of use thereof to inactivate a virus in contact with the face mask. The face mask may include a fibrous material with silicon nitride powder impregnated therein and a layer surrounding the fibrous material. In some embodiments, silicon nitride is present in the fibrous material at a concentration of about 1 wt. % to about 15 wt. %.

Antipathogenic face mask

Described herein are antiviral compositions and apparatuses and methods of use thereof to inactivate a virus in contact with the composition or apparatus. The composition and/or apparatus include silicon nitride at a concentration of 1 wt. % to 15 wt. % and the silicon nitride inactivates at least 85% of the virus in contact with the composition and/or apparatus.

Antiviral compositions and devices and methods of use thereof

Various embodiments related to systems, methods, and articles for rapid inactivation of SARS-CoV-2 by silicon nitride and aluminum nitride are disclosed herein.

Systems and methods for rapid inactivation of SARS-CoV-2 by silicon nitride and aluminum nitride

Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.

Antibacterial biomedical implants and associated materials, apparatus, and methods

Disclosed herein are antifungal composites, devices, and methods to reduce or prevent a fungus from growing on the antifungal composite. The antifungal composite and devices thereof may include a biocompatible polymer and a SiNpowder loaded in at least a portion of the biocompatible polymer. The polymer may be a thermoplastic polymer such as a poly(methyl methacrylate) (PMMA) resin and the SiNpowder may be present in a concentration of about 1 vol. % to about 30 vol. % in the thermoplastic polymer.

Antifungal composites and methods thereof

Methods for improving the antibacterial, osteoconductive, and/or osteoinductive characteristics of silicon nitride and/or other ceramic materials, particularly to make them more suitable for use in manufacturing biomedical implants. In some embodiments and implementations, the surface chemistry and/or morphology of a silicon nitride bioceramic may be modulated significantly through thermal, chemical, and/or mechanical treatments to achieve such advantageous results. A portion of the resulting material, such as a glaze or upper layer of the material, may be separately produced as a powder or frit, for example, and used in manufacturing biomedical implants and/or other products, such as by using such portion of the material as a coating or filler. In other embodiments the surface material may be separately manufactured as a silicon oxynitride monolith.

Ceramic and/or glass materials and related methods

Methods for threading ceramic materials, such as ceramic materials used for spinal implants or other biomedical implants. In some implementations, an expected rate of shrinkage of the block upon undergoing a firing process may be determined. A scaling factor may then be applied using the expected rate of shrinkage to select a tap having a size larger than a desired thread size. A green block may then be tapped with the selected tap to form a threaded opening in the green block. The block may be machined in order to remove cracks caused by the tapping process and/or to form the block into a desired shape/size. The green block may then be fired, which may result in a reduction of a size of the block and a size of the threaded opening.

Methods for threading sinterable materials and related apparatus and systems

Embodiments of apparatus, systems, and methods relating to biomedical implants and other devices made up of unique and improved alumina-zirconia ceramic materials. In an example of a method according to an implementation of the invention, a slurry is prepared, compressed, and fired to obtain a fired ceramic piece comprising at least aluminum oxide, zirconium dioxide, yttrium oxide, cerium oxide, strontium oxide, magnesium oxide, titanium dioxide, and calcium oxide. Some embodiments and implementations may comprise selected concentrations of one or more such compounds to yield certain preferred results.

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Sandy, UT, United States of America

Bryan J McEntire