Emory University

Other

Hadasit Medical Research Services and Development Ltd.

Bryan D Cox

Raymond F Schinazi

Franck Amblard

Christina Gavegnano

Dennis C Liotta

Lance L Hood

James P Snyder

Lawrence J Wilson

Eithan Galun

Longhu Zhou

Hilla Giladi

Leda Bassit

Seema Mengshetti

Chofit Chai

Anthony Prosser

Compounds, compositions and methods for modulating retinoic acid receptor-like orphan receptors (ROR) and associated diseases. Methods for treatment or prophylaxis of metabolic disorders, liver disorders or diseases, including NASH, immune disorders, central nervous system disorders, or cancer are disclosed.

Modulators of orphan nuclear receptors for NASH and other metabolic disorders

Nucleoside compounds, which in some embodiments include an alkynyl substituent at the 4'-position, compositions and methods for treating or preventing HIV and other viral infections, particularly where the virus is present in macrophages, microglia, and primary myeloid cells, and eliminating and/or treating infection in patients infected by these viruses, are disclosed.

Combined modalities for nucleosides and/or NADPH oxidase (NOX) inhibitors as myeloid-specific antiviral agents

The present invention is directed to compounds, compositions and methods for treating or preventing Zika virus. The compounds include pyrimidine and purine nucleosides and prodrugs thereof, including certain N-hydroxycytidine nucleoside derivatives, sulfasalazine, and various entry inhibitors.

Antiviral agents and nucleoside analogs for treatment of Zika virus

The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of viral infections such as HIV or for managing cancer.

Chemokine CXCR4 and CCR5 receptor modulators and uses related thereto

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Suwanee, GA, United States of America

Bryan D Cox