Other

Bryan D Bryson

Bonnie Berger Leighton

Brian Hie

A method of viral escape profiling is used in association with antiviral or vaccine development. The method begins by training a language-based model against training data comprising a corpus of viral protein sequences of a given viral protein to model a viral escape profile. The viral escape profile represents, for one or more regions of the given viral protein, a relative viral escape potential of a mutation, the relative viral escape potential being derived as a function that combines both 'semantic change,' representing a degree to which the mutation is recognized by the human immune system (i.e., antigenic change), and 'grammaticality,' representing a degree to which the mutation affects viral infectivity (i.e. viral fitness). Using the model, a region of the given viral protein having an escape potential of interest is identified. Information regarding the region is then output to a vaccine or anti-viral therapeutic design and development workflow.

Growing community of inventors

Boston, MA, United States of America

Bryan D Bryson