Seno Medical Instruments, Inc.

Seno Medical Intruments, Inc.

Bryan Clingman

Jason Zalev

Donald G Herzog

Gregory Schmid

William Ackerman

Sandra G Dykes

Alexander A Oraevsky

Sergey A Ermilov

Anthony Thomas Stavros

Andre Conjusteau

Peter Brecht

Vyacheslav Nadvoretskiy

Richard Su

Remie J Smith

Thomas G Miller

Elisa Gravis

Thomas Miller

Remie Smith

Alexander Oraevsky

Sergey Ermilov

Systems, methods and computer program products are provided for analyzing at least one of ultrasound (US) images or optoacoustic (OA) images (US/OA images), comprising: a display configured to display at least a first image from at least one of OA images or US images acquired in connection with an examination for a region of interest (ROI), the first image including a lesion, the first image overlaid with an interior ROI outline separating an internal zone from a boundary zone of the ROI, the first image overlaid with an exterior ROI outline separating the boundary zone from a peripheral zone; a graphical user interface (GUI); memory configured to store program instructions; and one or more processors configured to execute the programmable instructions to: obtain feature scores in connection with at least the boundary zone and peripheral zone of the first image; apply the feature scores to a classification model to obtain predictive result indicative of a trait of the lesion, the predictive result indicating at least one of a presence or absence of metastasis lymph nodes and several lymph nodal metastasis; and output the predictive result.

Optoacoustic feature score correlation to ipsilateral axillary lymph node status

A method is disclosed for generating sinograms by sampling a plurality of transducers acoustically coupled with the surface of a volume of tissue over a period of time after a light pulse at one wavelength, and after another light pulse at a different wavelength, and for processing those sinograms, reconstructing at least two optoacoustic images from the two sinograms, processing the two optoacoustic images to generate two envelope images and generating a parametric map from information in the two envelope images. In an embodiment, motion and tracking are determined to align the envelope images. In an embodiment, at least a second parametric map is produced from information in the same two envelope images. In an embodiment an ultrasound image is also acquired, and the parametric map is coregistered with and overlayed upon the ultrasound image, and then displayed.

System and method for acquiring optoacoustic data and producing parametric maps thereof

A system and method for performing optoacoustic classification prediction is provided. The method utilizes one or more processors in connection with receiving OA feature scores in connection with OA images collected from a patient examination for a volume of interest. The volume of interest includes a lesion. The method applies the OA feature scores to a classification model to obtain a predictive result indicative of a trait of the lesion.

Optoacoustic image analysis method and system for automatically estimating lesion traits

Systems, methods and computer program products are provided for reading and scoring ultrasound and/or optoacoustic (US/OA) images that include at least one of OA images or US images acquired in connection with an examination for a region of interest (ROI). The system displays a first image that has an interior ROI outline separating an internal zone from a boundary zone. In some aspects, feature scores are obtained in connection with at least the boundary zone and peripheral zone of the first image and the feature scores are applied to a classification model to obtain at least one of a prognostic result or predictive result indicative of a trait of the lesion. In accordance with some aspects, an order in which feature scores are entered is automatically managed to obtain for the at least one of the peripheral zone or the boundary zone before the feature score is obtained for the internal zone.

Method and system for managing feature reading and scoring in ultrasound and/or optoacoustic images

A serialized probe component for an optoacoustic device has a unique identifier associated therewith and includes, in an embodiment, an operative connection between a read-write memory and the optoacoustic device. Software adapted to generate and store logs in a read-write memory is executed on the optoacoustic device and stores logs concerning utilization of the serialized probe component on the read-write memory. A method for logging operational information concerning an optoacoustic device is further disclosed.

Optoacoustic component utilization tracking

Method and system for managing feature reading and scoring in ultrasound and/or optoacoustice images

Electromagnetic energy is deposited into a volume, an acoustic return signal from energy deposited in the volume is measured, and a parametric map that estimates values of at least one parameter as spatially represented in the volume is computed. A reference level of a region of interest is determined, and upper and lower color map limits are specified, with at least one of them being determined in relation to the reference level. The parametric map is then rendered in the palette of a color map by mapping the estimated values of the parametric map onto the color map according to the color map limits. Two wavelengths of energy can be applied to the volume, and the parametric map computation can be adapted by applying an implicit or explicit model of, or theoretical basis for, distribution of electromagnetic energy fluence within the volume pertaining to the two wavelengths. The actual electromagnetic energy fluence caused by each wavelength has a propensity, due to variability within the volume, to differ from the modeled or theoretical electromagnetic energy fluence.

Statistical mapping in an optoacoustic imaging system

A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.

Dual modality imaging system for coregistered functional and anatomical mapping

An optoacoustic imaging system includes a handheld probe and first and second pulsed light sources having a common output. The first and second light sources generate pulses of light at first and second predominant wavelengths, respectively. The handheld probe includes an ultrasound transducer array having an active end located at the distal end of the handheld probe for receiving an optoacoustic return signal. A sensor measures a portion of the light transmitted along the light path. A data acquisition samples the ultrasound transducer array during a predetermined period of time after a pulse of light from the first light source and during a predetermined period of time after a pulse of light from the second light source. The sampled data is stored. An image processing unit reconstructs a first optoacoustic image based on the sampled data corresponding to a pulse of light from the first light source and reconstructs a second optoacoustic image based on the sampled data corresponding to a pulse of light from the second light source. An energy normalizing unit computes a normalization factor based on a measurement from each sensor in the array and applies the normalization factor to data corresponding to the pulse of light.

Interframe energy normalization in an optoacoustic imaging system

A method for controlling an optoacoustic imaging system includes the steps of analyzing sinogram data values to identify variations, storing information concerning the variations, generating first and second sinograms, and processing the sinograms to mitigate the effect of the variations. In the analyzing step, sinogram data values are analyzed to identify one or more variations that are related to performance of one or more of the discrete components of the optoacoustic imaging system. The identified variations are then stored. A first sinogram is generated by sampling transducer elements acoustically coupled with a surface of a volume for a predetermined period of time after delivery of a pulse of light having a first wavelength, the first sinogram containing one channel for each of the transducer elements. A second sinogram is generated by sampling the transducer elements acoustically coupled with the surface of the volume for the predetermined period of time after delivery of a pulse of light having a second wavelength, the second sinogram containing one channel for each of transducer elements. The first and second sinograms are processed using the stored information to mitigate the effect of the identified variations on the respective sinogram.

System and method for providing selective channel sensitivity in an optoacoustic imaging system

An optoacoustic imaging system includes a hand-held imaging probe having a light emitting portion and an array of ultrasonic transducers. The probe includes an acoustic lens having an optically reflective material that operates to avoid image artifacts associated with light interactions with the acoustic lens. The optically reflective material may be a thin, highly optically reflective metallic layer. The acoustic lens may be formed from a material such as silicone rubber filled with titanium dioxide or barium sulfate that allows it to reflect and scatter light from illumination components with substantially no absorption of such light, and yet be optically opaque. The probe may include a housing that provides hypo-echoic encapsulation of the probe. An assembly of the array of ultrasonic transducers may include a hypo-echoic material. The probe may include optical windows, each comprising one or more anti-reflection coated plates with acoustic impedance matching that of tissues to be imaged.

Optoacoustic imaging system having handheld probe utilizing optically reflective material

Systems and methods for relaying electrical signals representing acoustic response of a volume of tissue to light and ultrasound stimulation. In an embodiment, a plurality of ultrasound transducers receive acoustic energy from the volume and generate electrical energy, which is transmitted via an electrical path to a relay system. The ultrasound transducers are operated at a wide band frequency of at least 1 MHz to 5 MHz to receive acoustic energy from the volume of tissue responsive to light stimulation and at a narrower band frequency to receive acoustic energy from the volume of tissue responsive to acoustic stimulation. The relay system relays the electrical signals to an optoacoustic system or an ultrasound instrument for further processing depending on whether the electrical signals resulted from ultrasound or light stimulation. In an embodiment, optoacoustic, ultrasound, or other images are generated from the electrical signals and may be coregistered, overlayed, or displayed.

System and method for mixed modality acoustic sampling

A method is disclosed for creating and outputting a masked parametric map (e.g., hemoglobin oxygenation) that reflects parameters in a first parametric map (e.g., relative oxygenation) and second parametric map (e.g., relative hemoglobin). In an illustrative embodiment, the method comprises steps of generating a first parametric map, generating a second parametric map, and then generating a masked parametric map that reflects parameters in the first and second parametric maps. The masked map may present information not readily apparent from the first parametric map and the second parametric map, and not obtainable from the first and second parametric maps independently. The first parametric map may be based upon portions of two optoacoustic images created using differing wavelengths of light. The first parametric map is reflective of areas within the volume of tissue that have a differing response to the longer wavelength light event compared to the shorter one. The second parametric map is reflective of areas within the volume of tissue that have a stronger response to the longer and shorter wavelength light events than the surrounding areas. A masked parametric map is output which is reflective of a combination of information in the first and second parametric maps. In an embodiment, the masked parametric map is generated by generating a mask reflective of a combination of information in the first and second parametric maps, and applying the mask to one of the first or second parametric maps to form the masked parametric map. In an embodiment, one or more of the parametric maps is coregistered with, and overlayed on an ultrasound image of the same volume of tissue before being output.

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Chandler, AZ, United States of America

Bryan Clingman