Eli Lilly and Company

Bryan B Molloy

Mitchell I Steinberg

Klaus K Schmiegel

Edward R Lavagnino

Lawrence J McShane

Paul Pranc

3-Aryloxy-3-phenylpropylamines and acid addition salts thereof are useful in blocking uptake of monoamines by brain neurons, and are thus effective in treating disorders of sleep, sexual performance, appetite, muscular function, and pituitary function.

Treatment of obesity with aryloxyphenylpropylamines

The present invention relates to a new class of alkylsulfonamidophenylalkylamines which are potent antiarrhythmic agents having good oral bioavailability properties.

Alkylsulfonamidophenylalkylamine compounds used for treating arrhythmia

Selective biogenic amine uptake inhibitors, 3-substituted phenyloxy-3-phenylpropyldimethylamines.

Substituted phenoxyphenylproply dimethylamines

Alkylsulfonamidophenylalkylamines

Radioiodine containing phenylbutylammonium salts are valuable imaging agents, particularly for the heart.

Imaging agents and method

Quaternary ammonium salts of certain phenylpropylamines and phenylbutylamines are useful antiarrhythmic drugs. A method for treating arrhythmia and prolonging the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such quaternary ammonium salts are disclosed.

Quaternary ammonium antiarrhythmic drugs

Certain secondary and tertiary para-nitrophenylalkylamines are potent antiarrhythmic agents which prolong the action potential duration of cardiac tissue. A method of treating re-entrant arrhythmias, and pharmaceutical formulations containing paranitrophenylalkylamines, are provided.

Para-nitrophenylalkylamines

3-Aryloxy-3-phenylpropylamines and acid additions salts thereof, useful as psychotropic agents, particularly as anti-depressants.

Arloxyphenylpropylamines

3-Aryloxy-3-phenylpropylamines and acid addition salts thereof, useful as psychotropic agents, particularly as anti-depressants.

Aryloxyphenylpropylamines

Quaternary ammonium salts of certain phenylbutylamines are useful antiarrhythmic drugs. A method for treating arrhythmia and prolonging the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such quaternary ammonium salts are disclosed.

Certain secondary and tertiary para-nitrophenylalkylamines are potent antiarrhythmic agents which prolong the action potential duration of cardiac tissue. A method of treating re-entrant arrhythmias, and pharmaceutical formulations containing para-nitrophenylalkylamines, are provided.

Para-nitrophenylalkylamines and pharmaceutical compositions

A method of treating re-entrant arrhythmias comprising administering an effective dose of tetra-alkyl quaternary ammonium salt is provided. Pharmaceutical formulations containing a tetra-alkyl quaternary ammonium salt as the active ingredient are disclosed.

Method of treating arrhythmia

1-Phenyl-3-(optionally substituted phenoxy)-propylamines, inhibitors of norepinephrine uptake.

1-Phenyl-3-(substituted phenoxy)propylamines

Aryloxyphenylpropylamines for obtaining a psychotropic effect

Trifluoromethylphenols are prepared by hydrogenation of the corresponding trifluoromethylbenzylethers.

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Indianapolis, IN, United States of America

Bryan B Molloy