University of Oklahoma

Allergan, Inc.

Dermamedics, LLC

Skinmedica, Inc.

Therametics, LLC

Bryan B Fuller

Charles R Engles

Brian Keith Pilcher

Compositions containing an effective dermatological disease-treating or dermatological condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle are disclosed. Methods of using the compositions are also disclosed.

Compositions for treatment of dermatological diseases and conditions and methods of use thereof

Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.

Compositions containing aromatic aldehydes and their use in treatments

Compositions for use in treatment of hyperpigmentation and methods of use thereof

Compositions containing an effective dermatological disease-treating or dermatological condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle are disclosed.

Compositions for use in treatment of dermatological diseases and conditions

The presently claimed and disclosed inventive concept(s) contemplates compositions comprising compounds, in particular dihydroeugenol (DHE) and/or isoeugenol (IE) and/or ethyl vanillin (EV) or salts, esters, ethers, or derivatives thereof, and methods for topically or systemically delivering them for treatment against inflammation-related and other dermatological conditions such as described herein. These DHE and/or IE and/or EV or salts, esters, ethers or derivatives thereof also are delivered to a measurable extent transepidermally or transdermally. In one of its method aspects, this presently claimed and disclosed inventive concept(s) is directed to a method for treating a patient with a dermatological disease or condition by topically administering to said patient a pharmaceutical or cosmetic composition comprising a pharmaceutically or cosmetically acceptable topical carrier and an effective dermatological disease, disorder or condition-treating amount of a formulation of DHE and/or IE and/or EV, or salts, esters, ethers, or derivatives thereof. In particular, the presently claimed and disclosed inventive concept(s) is directed to a method of using a composition comprising one or more of DHE and/or IE and/or EV or salts, esters, ethers, or derivatives for treating dermatologic diseases, disorders or conditions, aging effects related to decreasing production of collagen, elastin, or hyaluronic acid, or to hyperpigmentation. The formulations may further contain cinnamaldehyde.

Methods and compositions for treating dermatological diseases and conditions

Compositions containing aromatic aldehydes and their use in treatment

A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof, or effective .alpha..sub.2 -antagonists, skin for inhibiting melanogenesis in the skin leading to skin lightening. The yohimbine may be provided as a natural extract, for example, as an extract of Johimbe bark. The composition may include a skin exfoliant.

Method for causing skin lightening

A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof, or effective .alpha..sub.2 -antagonists to skin for inhibiting melanogenesis in the skin leading to skin lightening. The yohimbine may be provided as a natural extract, for example, as an extract of Johimbe bark. The composition may include a skin exfoliant.

Composition for causing skin lightening

A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof or effective .alpha..sub.2 -antagonists, to the skin for inhibiting melanogenesis in the skin leading to skin lightening. The yohimbine may be provided as a natural extract, for example, as an extract of Johimbe bark.

Growing community of inventors

Edmond, OK, United States of America

Bryan B Fuller