3m Innovative Properties Company

Solventum Intellectual Properties Company

Bryan A Baker

Jana Ninkovic

Jie Jerry Liu

Naiyong Jing

George W Griesgraber

Kurt J Halverson

Robert T Fitzsimons, Jr

Kevin D Landgrebe

David R Holm

Ranjani V Parthasarathy

Caleb T Nelson

Wensheng Xia

Jason W Bjork

Steven P Swanson

Amy K McNulty

Graham M Clarke

Semra Colak Atan

Timothy J Nies

Kiu-Yuen Tse

Alexi J Young

Minghua Dai

Giuseppe M Bommarito

David P Swanson

Federica Sgolastra

Wei Zhang

Ryan T Woldt

Raha A Been

Gary W Jorgensen

Amy K Mcnulty

Robert T Fitzsimons

Jie Liu

An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.

Negative pressure wound therapy article with features

A method of disinfecting a medical device comprises three steps. First, a disinfectant is contacted with a process indicator and the medical device. The disinfectant comprises at least one aldehyde. The process indicator contains a synthetic amine-containing compound disposed on a substrate. The synthetic amine-containing compound comprises at least one of primary amino groups or secondary amino groups, and is reactive with the disinfectant to form at least one adduct. The synthetic amine-containing compound and the medical device are in fluid communication through the disinfectant. A predetermined disinfectant exposure criterion exists for contacting the disinfectant with the medical device. Second, the process indicator is spectrally observed and at least one parameter is obtained therefrom that is predictive of the predetermined disinfectant exposure criterion. The third step is determining that the predetermined disinfectant exposure criterion has been achieved.

Method of disinfecting a medical device

A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.

Fibrin composition, method and wound articles

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Minneapolis, MN, United States of America

Bryan A Baker