Bayer Aktiengesellschaft

Bruno Rosen

Siegfried Zaiss

Siegfried Goldmann

Otto Behner

Hartmund Wollweber

Erwin Bischoff

Burkhard Fugmann

Hartmut Wollweber

Karlheinz Weber

Volker-Bernd Fiedler

Christian Kohlsdorfer

Rudi Grutzmann

Maarten De Jonge

Hartwig Muller

Klaus Frobel

Hans-Georg Dellweg

Guenther Karmann

Hartwig M Uller

Natural substance cyclamenol and chemical derivatives

The invention relates to the new dimethyl 4-(4-chloro-3-trifluoromethylphenyl) -1-cyclopropyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, a process for its preparation and its use as a medicament in ischaemic diseases which are associated with disorders of the microcirculation. This action can occur both in the peripheral and in the cerebral vascular system.

Specific 1,4-dihydropyridine-3,5-dicarboxylic acid ester, and its

Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl,

Haemorheological use of N-alkylated 1,4-dihydropyridine-dicarboxylic

The invention relates to the new dimethyl 2,6-dimethyl-1-n-propyl-4-(trifluoro-methylphenyl)-1,4-dihydropyridine-3-d icarboxylate, a process for its preparation and its use as a medicament in ischaemic diseases which are associated with disorders of the microcirculation. This action can occur both in the peripheral and in the cerebral vascular system.

Specific 1,4-dihydropyridine-3,5-dicarboxylic acid ester and its

N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be prepared either by reaction of aldehydes with acetoacetic esters and amines, optionally with isolation of the corresponding ylidene compounds, or by reaction of aminocrotonic acid esters with ylidene compounds and subsequent alkylation of the NH function. The N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be employed as active compounds in medicaments, in particular as cerebral therapeutics.

N-alkylated 1,4-dihydropyridinedicarboxylic acid esters

N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters

A method of treating a patient to reduce or prevent an acute or chronic inflammation or an ischaemic state which comprises administering to such patient an effective amount therefor of efomycin A, E or G.

Efomycins A, E and G as antiinflammatory agents

Growing community of inventors

Wulfrath, Germany

Bruno Rosen