Chiesi Farmaceutici S.p.a.

Bruno Pietro Imbimbo

Gino Villetti

Luca Raveglia

Andrea Rizzi

Ilaria Peretto

Stefano Radaelli

Simone Ottonello

Nadia Moretto

Rodolfo Berni

Dalila Mango

Elisa Landucci

Fabrizio Facchinetti

The present invention relates to a process for production of nerve growth factor (NGF) and muteins thereof, in particular muteins of human NGF. The process of the present invention yields nerve growth factor (NGF) and muteins thereof, e.g. from recombinant sources, at high purity. Aspects related to the process of the present invention, such as muteins obtainable thereby, are also described. The respective muteins may be characterized e.g. by improved detectability and/or reduced nociceptive activity, compared to wildtype human NGF.

Production of nerve growth factor (NGF) and of muteins thereof

Administration of certain 1-phenylalkanecarboxylic acid derivatives is useful for improving Cognitive Function; treating Cognitive Impairment, in particular Mild Cognitive Impairment; and preventing and/or reducing the risk of developing Alzheimer's Disease in a cognitively normal subject.

1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment

Derivatives of 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid are capable of stabilizing the tetrameric native state of transthyretin for the prophylaxis and treatment of amyloidosis.

1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis

Pro-drugs of 1-(2-halo-biphenyl-4-yl)alkanecarboxylic acids are useful for preventing and/or treating neurodegenerative diseases, improving cognitive function and treating cognitive impairment.

Derivatives of 1-(2-halo-biphenyl-4-yl)-Alkanecarboxylic for the treatment of neurodegenerative diseases

1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.

1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases

The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.

Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases

The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of A&#x3b2;42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Yrx). Polypeptides bearing multiple copies of A&#x3b2;42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Elicited antibodies were found to selectively bind to fibrillar and/or oligomers A&#x3b2; within neuritic AD plaques.

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Parma, Italy

Bruno Pietro Imbimbo