Commissariat a L'energie Atomique

Cis Bio International

Bruno Perly

Florence Djedaini-Pilard

Cecile Baudin

Roberto Pasqualini

Florence Pilard

Laurent Mauclaire

Jean-Claude Debouzy

Andr&eacute;e Gadelle

Florence Fauvelle

Andree Gadelle

Valerie Laine

Jacques Defaye

Nathalie Azaroual-Bellanger

Jing Lin

Yves Michel

C&eacute;cile Baudin

Rachel Auzely-Velty

C&eacute;cile Roselli

Stéphane Moutard

Patrick Rollin

Pascal Gosselin

The invention relates to cyclodextrin derivatives of formula (I): in which: The invention also relates to a process for preparing them, and to inclusion complexes and organized surfactant systems comprising them.

Amphiphilic cyclodextrin derivatives, method for preparation thereof and uses thereof

The invention provides cyclodextrin derivatives that may be used to transport hydrophobic molecules for pharmaceutical or cosmetic applications, by forming organised systems in an aqueous medium, alone or with phospholipids. The cyclodextrin derivatives of the present invention have the formula:in which, Rrepresents a steroid, Rrepresents an alkyl or aryl group, substituted if applicable, Rrepresents H or R, all the Rrepresent OR, or one of the Rrepresents &#x2014;NHCO(CH)CONHR, m is an integer ranging from 1 to 8, and n is equal to 5, 6 or 7.

Amphiphile cyclodextrins, preparation and use thereof for solubilizing organized systems and incorporating hydrophobic molecules

Complexes for immobilizing isothiocyanate natural precursors in cyclodextrins, preparation and use

Method for fixing or separating ions, in particular of lead, using per(3,6-anhydro)cy-clodextrin derivatives

Water purification using cyclodextrins

Radiopharmaceutical compositions that include an inclusion complex of a

The invention relates to derivatives of cyclodextrins, their preparation and their use for incorporating hydrophobic molecules into organized surfactant systems. These derivatives of cyclodextrins are in accordance with the formula: ##STR1## in which R.sup.1 represents a group protecting an amine function, the R.sup.2, which can be the same or different, represent OH or NH--CH.sub.2 m--NHR.sup.1,m being an integer from 2 to 18 and n is equal to 5, 6 or 7.

Derivatives of cyclodextrins, their preparation and their use for

The invention relates to the use of natural cyclodextrins and their derivatives for the solubilization of platelet anti-aggregating agents from the family of Ginkgolides. The cyclodextrins used comply with the formula: ##STR1## in which n is equal to 6, 7 or 8 and the R.sup.1, which can be the same or different, represent OH or SR.sup.2 with R.sup.2 representing a group derived from a monosaccharide or an oligosaccharide. The Ginkgolide is preferably Ginkgolide B.

Use of natural cyclodextrins and their derivatives for the

The invention relates to substituted derivatives of per(3,6-anhydro)cyclodextrins, their preparation process and their use for the separation of ions. These derivatives comply with one of the formulas: ##STR1## in which the R.sup.1, which can be the same or different, represent H, a halogen, OH, OR.sub.2, OM, SH, SR.sup.2, OCOR.sup.2, NH.sub.2, NR.sup.2 R.sup.3, CONR.sup.2 R.sup.3, CONH.sub.2, CN, COOR.sup.2, COOH, OSO.sub.2 R.sup.2, N.sub.3 or R.sup.2, and n=5, 6 or 7, provided that all the R.sup.1 do not represent OH.

Substituted derivatives of per (3,6-anhydro) cyclodextrins, their

Cyclodextrin derivatives usable in particular for solubilizing

Use of mono-3,6-anhydrocyclodextrins for solubilizing a hydrophobic

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La Verriere, France

Bruno Perly