University of Pennsylvania

Dana-farber-cancer Institute Inc.

Bryn Mawr College

Bruno Melillo

Amos B Smith, Iii

Adam T Hoye

Won-Suk Kim

Rongbiao Tong

Minh Huu Nguyen

Luis Sanchez

Dionicio Martinez-Solorio

Joseph G Sodroski

Judith M LaLonde

Amy M Princiotto

Navid Madani

The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region. In certain embodiments, the disclosure relates to the use of small molecules as microbicides to inhibit HIV-1 infection directly and to sensitize primary HIV-1 to neutralization by readily elicited antibodies.

Inhibitors of HIV-1 entry and methods of use thereof

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

Silicon-based cross coupling agents and methods of their use

Growing community of inventors

Philadelphia, PA, United States of America

Bruno Melillo