L'oreal

Bruno Mehul

Dominique Bernard

Lucie Simonetti

The invention provides a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, at least one purified natural or synthetic polypeptide wherein the peptide sequence is represented wholly or partly by at least one sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 16, SEQ ID NO: 25 and SEQ ID NO: 27 and their homologs.

Use of aspartic proteases in cosmetics and therapeutics

The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, and neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.

Isolated polypeptide of the stratum corneum and its use

The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.

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Gourdon, France

Bruno Mehul