Boehringer Mannheim Italia

Boehringer Biochemia Robin S.p.a.

Boehringer Mannhein Italia, S.p.a.

Bruno Lumachi

Silvano Spinelli

Sergio Tognella

Roberto Di Domenico

Licia Gallico

Ernesto Menta

Carmelo A Gandolfi

Odoardo Tofanetti

Compounds of formula I ##STR1## wherein Ar is an optionally substituted phenyl ring; B is a single bond, a group --(CH.sub.2 OCH.sub.2).sub.n being n=or 2, a a 2,4-disubstituted-1,3-dioxolane ring or a 2,4-disubstituted-1,3-thioxolane ring, R is a single bond, an optionally substituted methylene or ethylene group and T is 2, 3- or 4-pyridyl, an optionally salified or esterified carboxy group or a carboxyamide group. Said compounds are useful in treatment of respiratory diseases.

Ethers and thioethers having therapeutical activity, their preparation

.beta.-carbonyl-carboxyamides of 1,3-thiazolidines

Cyclic amino-thioacetal amides of formula I ##STR1## wherein X is O, S, p is 1 or 2, R and R.sub.1 are optionally esterified hydrogen or carboxy, A is a single bond, methylene or ethylene, m is zero or 1, n is an integer 1 to 7 and y is a imidazole or .beta.-pyridylmethyl residue. Compounds I have valuable therapeutic properties.

Cyclic amino-thioacetal amides, a process for the preparation thereof

Compounds of formula I ##STR1## wherein Ar is an optionally substituted phenyl ring; B is a single bond, a group --(CH.sub.2 OCH.sub.2).sub.n being n=1 or 2, a 2,4-disubstituted-1,3-dioxolane ring or a 2,4-disubstituted-1,3-thioxolane ring, R is a single bond, an optionally substituted methylene or ethylene group and T is 2-, 3- or 4-pyridyl, an optionally salified or esterified carboxy group or a carboxyamide group. Said compounds are useful in treatment of respiratory diseases.

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Milan, Italy

Bruno Lumachi