Aventis Pharma S.a.

Sanofi

Bruno Filoche-Rommé

Frank Halley

Michel Tabart

Alain Commercon

Baptiste Ronan

Eric Bacque

Patrick Mailliet

Fabrice Viviani

Youssef El-Ahmad

Augustin Hittinger

Fabienne Thompson

Conception Nemecek

Francois Clerc

Hervé Minoux

Victor Certal

Catherine Souaille

Sylvie Wentzler

Karl Andreas Karlsson

Marie-Pierre Cherrier

Jean-Philippe Letallec

Corinne Venot

The invention relates to the novel products of formula (I): 

1H-pyrimidin-2-one derivatives, preparation thereof and pharmaceutical use thereof as inhibitors of AKT (PKB) phosphorylation

Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as anticancer agents.

Substituted indoles, compositions containing them, method for the production thereof and their use

Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.

Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors

The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers.

Organophosphorus derivatives of indazoles and use thereof as medicinal products

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Creteil, France

Bruno Filoche-Rommé