The Scripps Research Institute

International Aids Vaccine Initiative

Bruno E Correia

Benjamin F Cravatt

William Ray Schief

Megan Blewett

Keriann M Backus

John R Teijaro

Daniel Kulp

Ron Jacak

Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.

Cysteine reactive probes and uses thereof

The present application relates to immunogens of broadly neutralizing monoclonal antibodies specific for HIV-1, such as broad and potent neutralizing monoclonal antibodies specific for HIV-1 and their gernation and methods of use. Broad neutralization suggests that the antibodies can neutralize HIV-1 isolates from different individuals. Immunogens or vaccines which may elicit such antibody associated responses are useful in pharmaceutical compositions for the prevention and treatment of HIV, and for the diagnosis and monitoring of HIV infection.

Immunogens of HIV-1 broadly neutralizing antibodies, methods of generation and uses thereof

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La Jolla, CA, United States of America

Bruno E Correia