Gruppo Lepetit

Merrell Dow Pharmaceuticals

Bruno Cavalleri

Adriano Malabarba

Paolo Strazzolini

Carolina Coronelli

Angelo Borghi

Giancarlo Volpe

Ambrogio Magni

Giancarlo Lancini

Aldo Trani

Romeo Ciabatti

Hermes Pagani

Enrico Selva

Marino Nebuloni

Marco Turconi

Pietro Ferrari

Emilio Occelli

Alessandro Assandri

Giovanni Tamborini

The invention concerns the aglycons of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686, their corresponding tetrahydroderivatives and mixtures thereof. The aglycons are produced by the selective hydrolysis of antibiotic A/16686 factor A1, A2, A3, A'1, A'2 or A'3. The compounds have antibacterial activity against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.

Aglycons of A/16686 antibiotics

Rifapentine hydrohalides

The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.

Composition of antibiotic L 17054 and a method for the treatment of

The invention concerns tetrahydroderivatives of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686 and mixtures thereof. The tetrahydroderivatives are produced by hydrogenation of the above mentioned factors, preferably by catalytic hydrogenation. The compounds have antibacterial activity, in particular, against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.

Hydrogenated derivatives of antibiotic A/16686

Process for preparing antibiotic L 17054

Carboxylic acid ester derivatives or deglucoteicoplanin

The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.

Ester derivatives of antibiotic L 17046

Process for preparing antibiotic L 17392 (deglucoteicoplanin)

The present invention concerns new 2'-substituted-4-deoxy-thiazolo[5,4-c]rifamycin SV derivatives having antibacterial activity. These compounds are compounds obtained by chemical modification of thiazolo[5,4-c]rifamycin SV.

2'-Substituted-4-deoxy-thiazolo(5,4-c)-rifamycin SV derivatives

The present invention refers to a process for transforming teicoplanin factor A.sub.2 component 1 into teicoplanin factor A.sub.2 component 3 by means of a chemical reaction which includes the catalytical hydrogenation of the substrate.

Process for transforming teicoplanin factor A.sub.2 component 1 into

The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called teicoplanin (formerly teichomycin) by chemical treatment. The new compound possesses antimicrobial activity expecially against gram-positive bacteria.

Antibiotic L 17046 and process for preparing it

This invention relates to a process for converting a teicoplanin-like compound into antibiotic L 17046 characterized in that a teicoplanin-like compound selected from teicoplanin complex, any further purified preparation thereof, teicoplanin factor A.sub.2, teicoplanin factor A.sub.3, each of the main components of teicoplanin factor A.sub.2, antibiotic L 17054 and a mixture of two or more of the above substances in any proportion is submitted to hydrolysis with a strong acid in the presence of a polar aprotic organic solvent selected from ethers, ketones and mixtures thereof that a room temperature are liquid.

Process for preparing antibiotic L 17046

The present invention is directed to a class of basic monocarboxyamide derivatives of actagardine. Actagardine (INN) is an antibiotic substance produced by actinoplanes strains such as Actinoplanes Sp. ATCC 31048 and Actinoplanes Sp. ATCC 31049 which are described in U.S. Pat. No. 4,022,884. Actagardine shows antimicrobial in vitro and in vivo activity against gram-positive organisms. Its complete chemical structure is not yet known but there is only information on its chemical functions and main fragments. In particular, it has been found that actagardine has two carboxylic functions and a primary amino function and can therefore be represented as follows: ##STR1## The compounds of the invention are monoamide derivatives at one of the carboxy functions of actagardine. More particularly, they are basic monoamide derivatives of actagardine which may be schematically represented by the following formula I: ##STR2## The compound of the invention possess improved antimicrobial activity in particular against gram positive bacteria.

Basic monocarboxyamide derivatives of actagardine having antibiotic

The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called teicoplanin (formerly teichomycin) by chemical treatment. The new compound possesses antimicrobial activity especially against gram-positive bacteria.

Growing community of inventors

Milan, Italy

Bruno Cavalleri