Jenike & Johanson, Inc.

Bend Research, Inc.

Pfizer Corporation

Bruno Caspar Hancock

David Bruce Hedden

Scott A Clement

James K Prescott

Thomas G Troxel

Dean Lance Brone

Michael A McCall

Dwayne Thomas Friesen

Ravi Mysore Shanker

David Keith Lyon

Marshall David Crew

James A S Nightingale

Douglas Alan Lorenz

Leah Elizabeth Appel

Rodney James Ketner

Ravi Mysore Shankar

John E Byers

Chris Macri

Stephen J Schadtle

James Alan Shriver Nightingale

Timothy J McDermott

Leah Elisabeth Appel

High loading immediate release dosage forms containing at least 30 wt % of a solid drug dispersion, at least 5 wt % of a disintegrant and a porosigen are disclosed that exhibit excellent strength and aqueous solubility.

Immediate release dosage forms containing solid drug dispersions

A solid amorphous dispersion comprises a cholesteryl ester transfer protein (CETP) inhibitor, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase inhibitor), and a concentration enhancing polymer. At least a major portion of the CETP inhibitor in the dispersion is amorphous. The solid amorphous dispersion provides concentration-enhancement of the CETP inhibitor when administered to an aqueous use environment.

Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors and HMG-CoA reductase

A dosage form comprises (1) a solid amorphous dispersion comprising a cholesterol ester transfer protein inhibitor and an acidic concentration-enhancing polymer and (2) an HMG-CoA reductase inhibitor. The solid amorphous dispersion and the HMG-CoA reductase inhibitor are combined in the dosage form so that the solid amorphous dispersion and the HMG-CoA reductase inhibitor are substantially separate from one another in the dosage form.

Dosage forms comprising a CETP inhibitors and an HMG-CoA reductase inhibitor

A method makes use of a minimally-shearing feeder mechanism supplying a desired flow of particulate solids mixture, with minimal to no sifting segregation to a desired location. The feeder methodology maintains a uniform concentration of each size of particle within the mixture.

Method of uniformly supplying a mixture of particulate solids

A bed of particulate solids is fluidized in a test chamber to yield multiple test samples for subsequent evaluation of segregation effects. A controlled stream of gas enters the chamber in a series of flow rate cycles each progressively increasing to a maximum rate of gas flow and then decreasing, the maximum rate increasing for successive cycles. An indicating function is formed from measurements of corresponding rates of gas flow and pressure across the bed. Upon termination of the fluidization, multiple samples are sequentially extracted from a single space at the bottom of the test chamber.

Method and apparatus for segregation testing of particulate solids

A method and apparatus enables testing of sifting segregation of a particulate solid mixture in a storage bin or hopper. The apparatus makes use of a convergently and divergently angled hopper for collecting the mixture. The apparatus further makes use of a minimally-shearing feeder mechanism supplying a desired flow of mixture, with minimal to no sifting segregation, to the angled hopper. A collection mechanism removes samples of the mixture from the angled hopper for analysis with minimal disruption of the particles of the mixture relative to each other. Thus, samples resulting from the testing apparatus, and corresponding method, are highly representative of mixture conditions within a larger storage hopper.

Method of segregation testing a mixture of particulate solids

Segregation testing apparatus for powders and granular materials

Pharmaceutical compositions of a particularly effective sparingly soluble glycogen phosphorylase inhibitor are disclosed, as well as methods of making such compositions and dosage forms from such compositions.

Pharmaceutical compositions of a sparingly soluble glycogen phosphorylase inhibitor

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North Stonington, CT, United States of America

Bruno Caspar Hancock