Centre National De La Recherche Scientifique

Université´ D'aix-Marseille

K.u. Leuven Research & Development

Bruno Canard

Jean-Louis Romette

Delphine Benarroch

Marie-Pierre Egloff

Barbara Selisko

Jan Balzarini

Johan Neyts

Karine Barral

Karine Alvarez

This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R-Rare as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and Ris selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and Chaloalkyl group.

Nucleotide analogues as precursor molecules for antivirals

The isolation and purification of two domains from a from ais provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide fromis also disclosed.

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The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.

Active truncated form of the RNA polymerase of flavivirus

This invention concerns an isolated and purified polypeptide capable of acting as a guanylyltransferase and methyltransferase comprising capping enzyme of(CEF). The invention also concerns the use of such polypeptide to identify biologically active molecule wich can be used in the treatment or the prevention of diseases resulting frominfection.

Capping enzyme of flavivirus and utilization of this protein in a process to test drugs with antiviral properties

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Cassis, France

Bruno Canard