Trophos

Bruno Buisson

Thierry Bordet

Cyrille Drouot

Rebecca Pruss

The present invention relates to the use of cholest-4-en-3-one derivatives for obtaining a cytoprotective drug, with the exception of a neuroprotective drug.

Use of cholest-4-en-3-one derivatives for obtaining a cytoprotective drug

A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I  

Method for providing neuroprotection

Method for providing neuroprotection from spinal muscular atrophy

Use as medicaments of derivatives of cholest-4-en-3-one, pharmaceutical compositions containing them, novel derivatives and their preparation process

The present invention relates to the use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug, with the exception of a neuroprotective drug, notably a cardioprotective or hepatoprotective drug.

Use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug

Compound of formula I where X=O or &#x2550;N&#x2014;OH group, A=hydrogen or together with B a carbon-carbon bond, B=hydrogen, hydroxy or together with A a carbon-carbon bond, C, D, E, F=hydrogen or together with D a carbon-carbon bond, or the one of its addition salts with pharmaceutically acceptable acids, with the exception of a few compounds, as a medicament, use in particular as neuroprotectors, novel compounds of formula I and pharmaceutical compositions.

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Marseilles, France

Bruno Buisson