Merck Serono S. A.

Applied Research Systems Ars Holding N.v.

Bruno Antonsson

Agnes Bombrun

Dennis Church

Serge Halazy

Jean-Claude Martinou

Patrick Gerber

Matthias Schwarz

Piperazine compounds for use as pharmaceutically active compounds and in pharmaceutical formulations that are useful for the treatment of disorders associated with apoptosis, including neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders, renal hypoxia, hepatitis and AIDS, where the piperazine compounds are represented by formula (I) and the terms R, R, R, R, k, l, m, n, and X are defined herein: 

9-(piperazinylalkyl) carbazoles as Bax-modulators

The present invention is related to piperazine derivatives of carbazole of formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such piperazine derivatives of carbazole. Said piperazine derivatives of carbazole are efficient modulators, in particular efficient inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel piperazine derivatives of carbazole as well as methods of their preparation.

9-(piperazinylalkyl) carbazoles as bax-modulators

The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.

Amine derivatives for the treatment of apoptosis

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Billiat, France

Bruno Antonsson