Shionogi, Inc.

Bruce X Cao

Beth A Burnside

Sandra E Wassink

Donald J Treacy, Jr

Colin E Rowlings

John A Bonck

Matt R Baker

Compositions and methods for making robust pellets that contain a high percentage, by weight, of active drug agent, and which also contain additional components that enhance the absorption and solubility of the active drug agent within the gastrointestinal tract (GI tract) without diminishing the robust nature of the pellet, are disclosed.

Robust pellet

A pharmaceutical tablet comprising an immediate release portion containing an active ingredient and a delayed release portion, wherein the delayed release portion comprises an enteric-coated layer and within the enteric-coated layer there is at least one member selected from the group consisting of enteric-coated microparticle dosage forms containing an active ingredient and enteric-coated mini-tablet dosage forms containing an active ingredient, is disclosed.

Tablet for pulsed delivery

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Germantown, MD, United States of America

Bruce X Cao