The Rockefeller University

Research, Incorporated

Sloan-Kettering Institute for Cancer

Bruce W Erickson

Tony E Hugli

Genevieve S Incefy

Kam-Fook Fok

Kazuhiro Ohga

Radioimmunossays for the quantitation of serum thymic factor (FTS), a thymic peptide hormone, are disclosed. Each assay employs an antibody specific for FTS, the monoclonal antibody or the antibody from the antiserum of a host animal; synthetic FTS or FTS analogue as the hormone standard; and a radiolabeled FTS analogue as the tracer. Also disclosed is a method of treating serum or other biological fluid prior to assay of FTS to remove interfering substances.

Radioimmunoassays for the serum thymic factor (FTS)

Solid phase synthesis of peptides and proteins have been improved by the use of a trifunctional segment, one functional group of which is bound to a solid support, the other two functional groups being available as substrates upon which identical proteins are synthesized.

Synthesis of peptides and proteins

Peptides containing at least four amino acid residues characterized by the presence of an amidino substituted .alpha.-amino acid such as arginine at the carboxyl terminus manifest activity to control smooth muscle contraction, histamine release and vascular permeability.

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Closter, NJ, United States of America

Bruce W Erickson