The Population Council, Inc.

Emisphere Technologies, Inc.

Bruce Variano

Shingai Majuru

William Elliot Bay

Satej Bhandarkar

John J Weidner

Maria Teresa Sallent

Lynn Sheilds

Simone Evans

Jeffrey Speck

The present disclosure relates to a vaginal system that prevents pregnancy comprised of segesterone acetate and ethinyl estradiol and is configured for thirteen 28-day product-use cycles.

System for providing birth control

Contraceptive

Multi-layered vaginal ringscomprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer, a middle layer, and an outer layer. After extrusion and simultaneous curing, however, the ringincludes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s)to the outer layer (s). Methods of producing these vaginal rings and of using them are also disclosed.

Multi-layered gradient vaginal ring

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well.

Compounds and compositions for delivering active agents

Growing community of inventors

White Plains, NY, United States of America

Bruce Variano