The Johns Hopkins University

Smithkline Beecham Corporation

Leonard Bloom

Bruce Scott Bochner

Kristine Kay Kikly

Connie L Erickson-Miller

Robert Schleimer

Julie A Abrahamson

T Esra Nutku

Howard N Robinson

Neil F Martin

Ronald L Schnaar

Francisco A Tausk

Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.

Sialoadhesin factor-2 antibodies

Methods of use of sialoadhesin factor-2 antibodies

The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the invention provides methods and compositions for the prevention and treatment of diseases and disorders associated with Siglec-8 expressing cells in humans, as well as other animals, through the administration of one or more novel, carbohydrate-based compounds.

Methods and compositions for treating diseases and disorders associated with siglec-8.

Methods and compositions for treating diseases and disorders associated with Siglec-8 expressing cells

SAF-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SAF-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Sialoadhesin family member-2 (SAF-2)

A slide having a portion thereof provided with transparent adhesive which adheres to a test sample. The slide and adhesive may be transparent. Specific types of infection and particularly fungal infections can be detected in the test sample using immunotest-methods. In a special embodiment the adhesive slide is fashioned with a peripheral lip or well to contain a test sample and a reagent.

Rapid test employing an adhesive slide

Polynucleotides encoding a sialoadhesin family member-2 (SAF-2)

Growing community of inventors

Lutherville, MD, United States of America

Bruce Scott Bochner