The General Hospital Corporation

Massachusetts Institute of Technology

Siemens Healthcare Gmbh

Other

Bruce R Rosen

Lawrence Leroy Wald

Bo Zhu

Matthew Scot Rosen

Thomas Witzel

Stefan Popescu

Himanshu Bhat

David Alan Boas

Peter Caravan

Elfar Adalsteinsson

Megan H Blackwell

Van J Wedeen

Bastien Guerin

Maria Angela Franceschini

Jason Stockmann

Robert J Miller

Giorgio Bonmassar

Stefan A Carp

Hans C Breiter

A Gregory Sorensen

Matti Hamalainen

Ovidiu Andronesi

Divya S Bolar

Barry E Kosofsky

John J A Marota

Joseph B Mandeville

Davide Tamborini

Oleg Shatrovoy

A system may transform sensor data from a sensor domain to an image domain using data-driven manifold learning techniques which may, for example, be implemented using neural networks. The sensor data may be generated by an image sensor, which may be part of an imaging system. Fully connected layers of a neural network in the system may be applied to the sensor data to apply an activation function to the sensor data. The activation function may be a hyperbolic tangent activation function. Convolutional layers may then be applied that convolve the output of the fully connected layers for high level feature extraction. An output layer may be applied to the output of the convolutional layers to deconvolve the output and produce image data in the image domain.

System and method for automated transform by manifold approximation

An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.

System and method for an optical blood flow measurement

Techniques are disclosed related to increasing prior limits imposed on MR gradient switching speed (dB/dt) without causing significant discomfort or severe pain perception to patients. The technique disclosed herein do so by modifying the pulsing gradient fields that are ordinarily available for MR imaging protocols. Doing so stimulates the peripheral nerves and thus enables a quick, reversible, and complete inhibition of action potential propagation through the stimulated region of tissue, referred to as a nerve conduction block.

Avoidance of peripheral nerve stimulation (PNS) using induced analgesia

Systems and methods for designing parallel transmission radiofrequency (RF) pulses for use in a RF treatment. The methods include selecting a target region in a subject, and providing a plurality of specific absorption rate (SAR) matrices for estimation of SAR at locations within the subject. The methods also include determining a first set of SAR matrices for locations in the target region using the provided SAR matrices, and determining a second set of SAR matrices for locations not in the target region using the provided SAR matrices. The methods further include designing a plurality of RF pulses for achieving a target power deposition in the target region by using the first set of SAR matrices and the second set of SAR matrices in an optimization that determines a set of RF waveforms that produce a target average local SAR using the first set of SAR matrices while minimizing a local SAR and a global SAR using the second set of SAR matrices.

System and method for hyperthermia treatment using radiofrequency phased arrays

A system acquires MR imaging data of a portion of patient anatomy associated with proton spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator configured to generate RF excitation pulses and a magnetic field gradient generator configured to generate anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator are configured to provide a rotating frame preparation pulse sequence comprising at least one of, (a) a T1 spin lattice relaxation in a rotating frame (T1&#x3c1;) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection and (b) a T2 spin-spin relaxation in a rotating frame (T2&#x3c1;) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection.

System for optimized low power MR imaging

Spin-lock T-weighted images of a subject are acquired and processed to produce an image that is indicative of bioelectromagnetic activity in the subject. A spin-lock RF field Bis produced such that the Larmor frequency in the rotating frame corresponds to the expected frequency of the bioelectromagnetic activity. As a result, the magnetic field fluctuations generated by the bioelectromagnetic currents shorten the Tof the surrounding tissue, creating a contrast mechanism that is seen as a reduced MR signal in the T-weighted image that is produced.

Stimulus induced rotary saturation for magnetic resonance functional imaging

A system and method for producing an image of a subject with a magnetic resonance imaging system, in which the image depicts an image contrast indicative of rotary saturation produced in response to magnetic particles administered to the subject, are provided. An agent that includes magnetic particles is administered to the subject. An electromagnetic drive field is applied to the subject at a drive frequency so that the magnetic particles produce magnetic fields that oscillate at the drive frequency and harmonics thereof. A spin-lock field is then established at a spin-lock frequency that is a harmonic of the drive frequency in order to produce rotary saturation of nuclear spins affected by the magnetic fields produced by the magnetic particles. Image data is then acquired from the subject using the MRI system, from which an image of the subject that depicts an image contrast indicative of the produced rotary saturation is reconstructed.

Method for magnetic resonance imaging using saturation harmonic induced rotary saturation

A system and method for accurately producing MR images of selected vascular compartments includes employing a control scan and a tag scan, each including velocity selective modules that suppress signal from blood flowing faster than a given cutoff velocity, to acquire control and tag sets of NMR data that may be subtracted to produce a compartment-specific MR image that is substantially free of information from stationary tissues and blood outside the selective vascular compartments. Accordingly, physiological parameters, such as oxygen saturation (SaO), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO), can be generated from the compartment-specific images. Further still, kinetic curves of oxygen exchange can be created, thus providing detailed insight into oxygen exchange dynamics.

System and method to analyze blood parameters using magnetic resonance imaging

An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.

Deep brain stimulation implant with microcoil array

A method and system for producing an image of a subject with a magnetic resonance imaging (MRI) system, in which the presence of a contrast agent is detected using a spin-lock pulse sequence, is described. More specifically, a contrast agent that induces saturation of magnetic resonance signals responsive to a spin-lock condition is administered to a subject. A spin-lock condition is subsequently established to saturate spins in proximity to the contrast agent. Image data is then acquired with an imaging pulse sequence and images indicative of the presence of the contrast agent are reconstructed.

Method for magnetic resonance imaging using stimulus induced rotary saturation with a contrast agent

A method for correcting subject motion in positron emission tomography (PET) imaging includes acquiring navigator signals from the subject with a magnetic resonance (MR) imaging system. The navigator signals are used to determine subject motion during a PET scan relative to a reference position and corrective values therefrom. Sinogram data acquired during the PET scan can then be corrected using the corrective values. PET images are then reconstructed from the corrected sinogram data.

Motion correction of PET images using navigator data acquired with an MRI system

The present invention is directed to baking apparatuses that are adapted for use in baking cakes, custards and other dishes that involve the use of a water bath. In a disclosed embodiment of the invention a baking apparatus is disclosed that includes an inner and outer pan, which may be formed as an integral unit. The outer pan is preferably adapted to receive and hold water and the inner pan is adapted to receive a springform containing a cheesecake batter or other mixture. The side or sides of the inner pan are preferably watertight and prevent leakage of water into the inner pan. The present invention offers the advantage of water bath baking without the problem of water from the bath leaking into the springform that contains the cake batter.

Baking apparatuses and methods of use

The invention provides methods for inhibiting psychostimulant-induced or nicotine-induced craving of additional psychostimulants (e.g., cocaine or amphetamine) or nicotine. In these methods, D1-like antagonists or D1-like agonists are administered to a patient dependent on psychostimulant drugs or nicotine and therefore susceptible to, or suffering from, such a craving. Also disclosed is an animal model system useful for measuring the ability of test compounds to inhibit pyschostimulant-induced or nicotine-induced cravings in humans.

Inhibition of psychostimulant-induced and nicotine-induced craving

Nuclear magnetic resonance apparatus for forming an image representative of a velocity profile of a fluid flowing in a vessel in which the fluid is stimulated to produce a time-dependent magnetic resonance signal, Fourier-transformed data is derived from the time-dependent magnetic resonance signal, the stimulating is done so as to introduce, into a predetermined component of the Fourier-transformed data, spatially-dependent phase information indicative of the velocity profile of the fluid, and the predetermined component is extracted for display as the image representative of the velocity profile.

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Cambridge, MA, United States of America

Bruce R Rosen