Agilent Technologies, Inc.

Advanced Analytical Technologies, Inc.

Bruce R Boeke

Martin Chris Foster

Thomas J Kurt

Scott Stueckradt

Wei Wei

Michael Stebniski

James D Morrow

Ho-ming Pang

Steven J Lasky

Mark D McClure

Mark R Ver Meer

Jolita J Uthe

A capillary electrophoresis system includes a capillary reservoir. The capillary reservoir includes a capillary tip flow chamber configured to receive respective capillary tips and to conduct fluid past the capillary tips, and an electrode flow chamber in which an electrode is disposed and configured to conduct fluid past the electrode, the electrode flow chamber being separate from and in fluid communication with the capillary tip flow chamber. An ultraviolet (UV) light absorbance-based multiplexed capillary electrophoresis system includes a first enclosure and a second enclosure. The first enclosure covers a UV light source, and includes a slit. The second enclosure covers the first enclosure, a collimating lens, and a capillary window.

Capillary electrophoresis system

The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. An additional mechanical stage moves the array from side-to-side. The x-z stage, coupled with the additional array stage allows the system to sample all wells of a 384 well plate with a 96-capillary array. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress.

Highly automated capillary electrophoresis system

UV-absorbance multichannel capillary electrophoresis system

The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress.

The invention is a multiplex, pulsed-field capillary electrophoresis instrument with the ability to analyze DNA fragments with sizes greater than 150,000 base pairs. The parallel capillary electrophoresis system allows for the simultaneous analysis of at least 12 samples while applying a pulse or varying electric field for separation. Sequences of pulse-field electric fields are iterated to achieve accurate separation of DNA smears.

Pulse-field multiplex capillary electrophoresis system

Laboratory instrument housing

The invention is a high-throughput multi-capillary system utilizing a 2-dimensional mask onto which the detection windows of the capillaries are lined up in alternating columns and rows. The image of the capillaries is projected onto a 2-dimensional detection system, such as a charge-coupled-detector (CCD) array. Each row and column of the capillary detection windows is imaged in a separate area of the CCD array, which results in reduced cross-talk between capillaries.

Method for the reduction of cross talk in multiplex capillary electrophoresis

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Ames, IA, United States of America

Bruce R Boeke