Northwestern University

Kensey Nash Corporation

Knc Ner Acquisition Sub, Inc.

Other

National Science Foundation

Nerites Corporation

Bruce P Lee

Phillip Byron Messersmith

Jeffrey L Dalsin

John L Murphy

Laura Vollenweider

Fangmin Xu

Murat Guvendiren

Kenneth R Shull

Arinne N Lyman

Sunil Silvary

William D Lew

Amanda Spitz

Jediah White

Lijun Lin

Haeshin Lee

Daniel A Sherman

Andrea R Statz

Sean A Burke

Haeshin Hl Lee

Jeanne Virosco

Jed White

Kul Huang

Michael Brodie

The invention describes new synthetic medical adhesives and films which exploit the key components of natural marine mussel adhesive proteins.

Adhesive compounds and methods use for hernia repair

The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.

Multibranched bioadhesive compounds and synthetic methods therefor

The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling.

Multi-armed catechol compound blends

The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface.

Surface independent, surface-modifying, multifunctional coatings and applications thereof

Adhesive polymeric compositions which can comprise dihydroxyphenyl moieties and derivatives thereof, and related methods of use.

Polymeric compositions and related methods of use

The invention relates generally to thin-film adhesive materials suitable for various applications. In particular, the present invention provides pliable viscoelastic thin-films configured to form strong water-resistant adhesive bonds to various surface types.

Thin film compositions and methods of synthesis and use therefor

The invention describes DOPA functionalized, branched, polyalkylene oxide materials that are useful as adhesives.

DOPA-functionalized, branched, poly(aklylene oxide) adhesives

Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

Biomimetic compounds and synthetic methods therefor

Nano-scale or micro-scale adhesive structures comprising an array of nano-fabricated, pillars, the pillars having coated upon, or having disposed on a working surface thereof, a protein-mimetic, marine-adhesive coating. Methods of fabricating the nano-scale pillars, synthesis of the protein-mimetic coating or wet adhesive and application of the adhesive to the pillars are described.

Biomimetic modular adhesive complex: materials, methods and applications therefore

The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive constructs can be used to treat and repair, for example, hernias and damaged tendons.

Bioadhesive constructs

A method of creating a bioadhesive in a substantially aqueous environment is disclosed. The method includes the steps of placing an anionicially polymerized block copolymer containing an amide, which is prepared by reacting a difunctional anionic initiator with a sterically hindered ester of methacrylic acid (SEMA), into a solvent to allow the solvent to swell the block copolymer; reacting the anionically polymerized hindered ester of methacrylic acid with methacrylic acid (MMA); hydrolyzing the anionically polymerized block copolymer with an aqueous solution to afford a methyl methacrylate-methacrylic acid-methyl methacrylate block copolymer (MMA-MAA-MMA); reacting the MMA-MAA-MMA block copolymer with 3,4-dihydroxyphenyl alanine to afford an amide with the MAA portion of the block copolymer; and placing the solvent swollen block copolymer in water. The water is exchanged with the solvent to provide a bioadhesive in an aqueous environment.

Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives

A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate) is disclosed.

A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate).

Growing community of inventors

Madison, WI, United States of America

Bruce P Lee