Janssen Pharmaceutica Nv

Janssen Research & Development, LLC

Bruce P Damiano

Patricia Andrade-Gordon

Raymond W Colburn

Tom Parry

Margery Connelly

Lisa Minor

Edward C Giardino

Christopher Van Besien

Robert Schulingkamp

Jianshen Qi

Dennis Stone

A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound.

Animal model for evaluating vasomotor response in vivo

Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the U-II/UT receptor. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the redness or the skin temperature of the ear of an animal, and the use of the methods to test compounds for their abilities to increase or decrease the biological activity of an U-II receptor.

Method of measuring the biological activity of an urotensin II receptor

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Warrington, PA, United States of America

Bruce P Damiano