Harvard College

The General Hospital Corporation

Children's Medical Center Corporation

Cliff-cartwright Corporation

Flex Pharma, Inc.

Bruce P Bean

Clifford J Woolf

Roderick MacKinnon

Donald MacKinnon

Jinbo Lee

David P Roberson

Sebastien Talbot

Sooyeon Jo

The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.

Charged ion channel blockers and methods for use

The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.

Permanently charged sodium and calcium channel blockers as anti-inflammatory agents

Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.

Methods of treating muscle cramping and related compositions

The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.

Methods, compositions, and kits for treating pain and pruritis

Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise

Growing community of inventors

Waban, MA, United States of America

Bruce P Bean