Sirtex Medical Limited

Paragon Medical, Inc.

Pine Ridge Holding Pty. Ltd.

Pine Ridge Holdings Pty Ltd.

Bruce Nathaniel Gray

Stephen Keith Jones

Andrew John Ruys

Yan Chen

Raffaele Cammarano

Katrina Francis Rutherford

The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix stably incorporated radionuclide, processes for its production and method of radiation therapy utilising the particulate material.

Polymer based radionuclide containing particulate material

The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass, the glass having a density of less than 2.5 g/cm, processes for its production and a method of radiation therapy utilising the patentable material.

Low density radionuclide-containing particulate material

Surgical retractor blade

A magnetic material having a magnetic heating efficiency of at least 4.5&times;10 J.m/A.g in a cyclic magnetic field where the product of the amplitude and frequency of the applied field is less than or equal to 5&times;10 A/m.s, and the frequency of the applied filed is at least 20 kHz. The ideal magnetic material is characterized by a perfectly rectangular hysteresis loop, i.e. loop squareness of 1, with coercivity of 25 kA/m or less and high saturation magnetization. Preferably the magnetic material has a predominately cubic magnetic crystalline anisotropy. Preferably the magnetic material is a substituted magnetite (Fe O ) or &ggr;-ferric oxide (&ggr;Fe O ) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metals atoms. Desirably, the metal atom is a member of the group: cobalt, zinc, nickel, manganese, magnesium, copper, chromium, gallium, cadmium.

Heating of magnetic material by hysteresis effects

A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5&times;10 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5&times;10 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5&times;10 A/s to generate hysteresis heat in the diseased tissue.

Targeted hysteresis hyperthermia as a method for treating diseased tissue

Particulate material

A clamping device (,) for clampingly interconnecting a first elongate element (,) and a second elongate element (,). The clamping device (,) comprises a shaft (,), and a first clamping member (,) mounted on the shaft. The first clamping member (,) has first and second clamping sections (,) between which the first elongate element (,) can be slidingly received and clampingly engaged. An aperture (,) is provided in the shaft (,) adjacent the second section (,) of the first clamping member (,) to slidingly receive the second elongate member (,). A second clamping member (,) is mounted on the shaft (,) and is displaceable therealong for clamping the second elongate element (,) between the first clamping member (,) and the second clamping member (,). A cam locking mechanism (,) is operably connected to the shaft (,) for selectively moving the clamping device between clamping and non-clamping conditions. In moving the clamping device (,) into the clamping condition, the cam locking mechanism (,) causes displacement of the second clamping member (,) along the shaft (,) such that the second elongate element (,) is clampingly engaged between the first clamping member (,) and the second clamping member (,).

Clamping device

A particulate material which comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns. The material may comprise a beta- or gamma-emitting radionuclide and be used in selective internal radiation therapy (SIRT) of various forms of cancer and tumours.

Hollow or cup-shaped microparticles and methods of use

A ball and socket interconnection capable of use in surgical retractor systems comprising a ball member and a socket member, the socket member defining an entry and being adapted to releasably receive the ball member such that when the ball member is received in the socket member it is capable of pivotal and rotational movement within the socket, the ball member having two spherical end surfaces between which is located an intermediate section, the spherical end surfaces having a radius of curvature greater than the radius of curvature of the entry and the intermediate section having a radius of curvature less than the radius of curvature of the entry, whereby the intermediate section renders the ball member releasably receivable in the socket member.

Ball and socket interconnection and retractor assembly employing the same

The present invention provides an improved method for treatment of diseased tissue, which comprises the steps of:

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Claremont, Australia

Bruce Nathaniel Gray