The University of British Columbia

Bruce McManus

David Granville

Ciara Chamberlain

Rani Cruz

Wendy Boivin

Raymond Ng

Zsuzsanna Hollander

Virginia Chen

Don D Sin

Robert Balshaw

Wendy Bolvin

Paul Keown

Robert McMaster

Andrew Ignaszewski

Casey Shannon

Darlene Dai

Karen Lam

Janet Wilson-McManus

Scott Tebbutt

The present disclosure relates to methods of diagnosing acute rejection of a cardiac allograft in a subject using genomic expression profiling, proteomic expression profiling, or both on panels of nucleic acid markers and proteomic markers.

Biomarkers for the detection of acute rejection in heart transplantation

Described are compositions and methods for diagnosing acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Multiple reaction monitoring mass spectrometry (MRM-MS) was used to quantify the amount of protein biomarkers in plasma samples from human subjects. The amount of the biomarkers in the sample can distinguish AECOPD from a stable or convalescent state of COPD, or from a subject without COPD.

Methods and systems of detecting plasma protein biomarkers for diagnosing acute exacerbation of COPD

A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin.

Granzyme A and granzyme B diagnostics

A method of medical treatment or prevention of a vasculopathy, comprising administering a therapeutically effective amount of a granzyme B inhibitor to a subject in need thereof is provided. In other aspects uses of Granzyme B inhibitors for treatment or for preparation of medicaments for treatment of a vasculopathy are provided.

Treatment of dissection, aneurysm, and atherosclerosis using granzyme B inhibitors

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Vancouver, Canada

Bruce McManus