Beckman Coulter, Inc.

Coulter Corporation

Bruce M Weber

Valentin T Quesada

Robert E Auer

James C Wood

John D Starling

Provided are high-resolution parametric signal restoration systems, and applications thereof. Such systems include a multi-output module and a parametric compensator. The multi-output module provides a reference gain output signal and one or more higher gain output signals based on a single input signal. The parametric compensator independently responds to functional parameters of the one or more higher gain output signals to provide a compensation error signal. The single input signal is modified based on the compensation error signal.

High-resolution parametric signal restoration

A flow cytometer includes a plurality of detectors for providing voltage pulse signals over a four decade range as particles pass through an illuminated detection station. Each voltage pulse signal is processed and provided to a first sample and hold for storage. Thereafter, the value in the first sample and hold is amplified by one or thirty-two, depending upon its magnitude, and stored in a second sample and hold for subsequent provision to a sixteen bit analog to digital convertor (ADC), one signal at a time. The first sample and hold is then free to store a new value while the old value is awaiting provision to the ADC. The ADC converts the signal received from the second sample and hold to a fifteen bit digital signal and uses the sixteenth bit to manifest whether the signal stored in the second sample and hold was amplified by thirty-two.

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Cooper City, FL, United States of America

Bruce M Weber