Surmodics, Inc.

Heraeus Medical Components LLC

Bruce M Jelle

Nathan Lockwood

Joram Slager

Aleksey V Kurdyumov

Joseph Schmidt McGonigle

David E Babcock

Timothy M Kloke

Gary Rabindranath Maharaj

Robert W Hergenrother

Gary W Opperman

Andrew G Bach

Teryl L Woodwick Sides

Sean Lundquist

Charlie Olson

Rick Murphy

Joe McGonigle

Ambereen Angamuthu

Anh Tri La

Dale G Swan

Sarah M Richardson-Burns

Jeffrey L Hendricks

Kyle Mallires

Sarah A Spanninga

Nathan A Lockwood

The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body () that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (), a tapered distal end (), and a locking mechanism () at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.

Insertion tools for medical device

A hemodialysis vascular access device includes a proximal end sized and shaped to sealably couple to a hemodialysis catheter, a movable structure coupled to the proximal end, a fixation structure coupled to the movable region and sized and shaped for fixation on a patient, an elongated sleeve coupled to the fixation structure and sized and shaped for insertion into a patient's vasculature, and a valve at a distal end of the internal lumen. When a hemodialysis catheter is inserted into the device and coupled to the proximal end, distal movement of the proximal end relative to the fixation structure biases a distal end of the hemodialysis catheter from a position inside the elongated sleeve through a valve out of the device and into the patient's blood.

Hemodialysis catheter sleeve

Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 &#x3bc;m or greater) which is very desirable for in vivo use.

Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers

Embodiments herein include an insertion tool for inserting a medical device into another medical device, such as a hemostasis sealing valve, and related methods. In an embodiment, an insertion tool includes a guide sheath and a protection tube. The guide sheath can include a flared proximal end. The guide sheath can further include a central lumen. The guide sheath can further include a locking notch disposed on the inner surface between the proximal end and the distal end. The protection tube can include a flared proximal end. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube can be sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

Two-part insertion tool and methods

The invention includes conductive polymeric coatings, medical device, coating solutions and methods of making the same. A coating solution for forming a conductive polymer layer can include a conductive monomer, at least one photoreactive component comprising an anionic photoreactive cross-linking agent or an anionic photoreactive hydrophilic polymer, and a solvent. A medical device can include an electrode and an electrically conductive coating disposed over the electrode. The electrically conductive coating can include a reaction product of the conductive monomer and the at least one photoreactive component. Other aspects are included herein.

Conductive polymeric coatings, medical devices, coating solutions and methods

Insertion tools for medical devices and methods for using

The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.

Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence

The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.

Hydrophilic polymeric coatings for medical articles with visualization moiety

Silane-functionalized hydrophilic polymers and polymeric matrices are described. Hydrophilic matrices can be formed from the polymers, and can be used in association with the preparation of implantable and injectable medical devices. Exemplary devices include those having a durable lubricious coating formed from the hydrophilic polymers.

Silyl ether-modified hydrophilic polymers and uses for medical articles

An inorganic substrate with two or more coating layers is provided. The first coating layer is attached to the inorganic substrate and includes the polymeric reaction product formed upon hydrolysis of a silane compound having at least two tri(C -C )alkoxysilyl groups. The second and subsequent coating layers include at least one hydrophilic polymer and at least one photoactivatable cross-linking agent. The inorganic substrate can be a medical device suitable for insertion into the body of a mammal. The coatings are tenacious and not easily removed from the inorganic substrate by abrasion.

Silane coating composition

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Chanhassen, MN, United States of America

Bruce M Jelle