The Mclean Hospital Corporation

Temple University

The Mcleon Hospital Corporation

Bruce M Cohen

Anne M Cataldo

William A Carlezon

Lee-yuan Liu-Chen

Perry F Renshaw

Katharine K Duncan

Thomas Anthony Munro

Beth L Murphy

Cecile Beguin

Cécile Béquin

Minsheng He

David Yue-Wei Lee

Michele R Richards

Justin Stephen Potuzak

Chun-Wei Chen

Yong Ke

The invention features methods, kits, and compositions for mitochondrial replacement in the treatment of disorders arising from mitochondrial dysfunction. The invention also features methods of diagnosing neuropsychiatric (e.g., bipolar disorder) and neurodegenerative disorders based on mitochondrial structural abnormalities.

Methods and compositions for mitochondrial replacement therapy

The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.

Salvinorin derivatives and uses thereof

In general, the invention relates to marrow-derived adult progenitor cells (MAPCs) and their use in methods of treating various medical disorders, typically caused by or involving loss of cells or loss of cell function. These cells, when administered, e.g., intranasally, can cross the blood brain barrier and terminally differentiate into cholinergic neurons or otherwise localize and terminally differentiate.

Methods and compositions for the treatment of medical disorders

The invention features methods of treating mood disorders, such as manic disorders, and stabilizing moods by administering a kappa agonist or partial agonist to a subject in need thereof.

Methods for the treatment of mood disorders

The invention features methods of selecting chemical peaks from two-dimensional magnetic resonance spectra for one-dimensional extraction and quantification methods using these one-dimensional extractions. The methods permit enhanced differentiation of particular peaks in two-dimensional magnetic resonance spectroscopy and allow for quantification of chemical concentrations in test samples, such as human brain tissue, having complex magnetic resonance spectra due to the presence of numerous chemicals. These new techniques can be used to provide information about the concentrations of a variety of chemicals, including metabolites, in both biological and non-biological media.

Two-dimensional MR spectroscopy techniques

Growing community of inventors

Lexington, MA, United States of America

Bruce M Cohen