Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

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Jefferson Wright Tilley

Matthew Michael Hamilton

Alexander Mayweg

Paul Gillespie

Robert Alan Goodnow, Jr

Nancy-Ellen Haynes

Nader Fotouhi

Sherrie Lynn Pietranico-Cole

Kevin Richard Guertin

Kshitij Chhabilbhai Thakkar

Nathan Robert Scott

Agnieszka Kowalczyk

Giuseppe Federico Weber

Joseph Anthony Bilotta

Michael Paul Myers

Alexander V Mayweg

Robert Alan Goodnow Jr

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

Pyrazolones as inhibitors of 11&#x3b2;-hydroxysteroid dehydrogenase

Compounds of the formula ##STR1## wherein R is hydrogen, alkyl.sub.1-8, geminal alkyl.sub.1-3, unsubstituted or substituted aryl; X is alkylene, --CR.sub.1 .dbd.CR.sub.2 -- (E and/or Z), carbonyl, oxygen or sulfur, wherein one of R.sub.1 and R.sub.2 is alkyl.sub.1-3 and the other is hydrogen; Y is unsubstituted alkyl.sub.1-12 or substituted by one or more alkyl.sub.1-3 groups, or unsubstituted or substituted phenylalkyl .sub.1-3 ; or a salt thereof with a pharmaceutically acceptable base, are described. The compound of formula I are potent inhibitors of phospholipase A.sub.2 (PLA.sub.2) and are therefore useful in the treatment of inflammatory diseases, such as, psoriasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary, myocardial ischemia and trauma induced inflammation, such as, spinal cord injury.

Substituted tetrahydrobenzopyrrolylfuranoic acid derivatives as

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