Immulogic Pharmaceutical Corporation

Merck Patent Gmbh

Other

The University of North Carolina at Chapel Hill

Immulogic Pharamaceutical Corp.

Immulogic Pharmaceutical Co.

Heska Corporation

David G. Klapper

Thorunn Rafnar

Bruce Rogers

Mei-chang Kuo

Bruce L Rogers

Julia L Greenstein

Richard D Garman

Jay Paul Morgenstern

Wayne Robert Thomas

Kaw-Yan Chua

Ze'ev Shaked

Xian Chen

David G Klapper

Henry M Franzen

Sean Evans

Julian F Bond

Irwin J Griffith

Malcolm Morville

Malcolm L Gefter

Andrew W Brauer

Bradford T Sorensen

Thomas J Briner

Ze&prime;ev Shaked

Steven S Leonard

Mei-Chang Kuo

A planting device may include a platform having a top surface, a bottom surface, and an aperture. Either a projection that extends from the bottom surface or a planting tube that extends from the top surface may be configured couple to the aperture. The projection and the planting tube may be interchangeable. The planting device may further include a handle extending from the top surface.

Seed planting device and method of use

Isolated nucleic acids encoding an allergen of, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

[object Object]

Isolated nucleic acids encoding an allergen of,III, are disclosed. A cDNA encoding a peptide having aIII activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence ofIII nucleic acid in a sample or for the recombinant production of peptides having an activity ofIII. Peptides having an activity ofIII can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.

Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor

The present invention provides isolated peptides of the major protein allergens of the genus. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.

T cell epitopes of the major allergens from dermatophagoides (house dust mite)

The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.

Recombitope peptides

Isolated nucleic acids encoding an allergen of III, are disclosed. A cDNA encoding a peptide having a III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of III nucleic acid in a sample or for the recombinant production of peptides having an activity of III. Peptides having an activity of III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

Nucleic acids encoding a house dust mite allergen Der p III, and uses therefor

Antigen E or I of ragweed pollen has been shown to be a family or families of proteins. cDNAs encoding I, the major human allergen of ragweed and II, peptides derived from I or II, antibodies against the peptides; and methods of treating individuals for sensitivity to ragweed are disclosed.

Allergenic peptides from ragweed pollen

Methods for treating sensitivity to protein allergen using peptides which include a T cell epitope recognized by a T cell receptor specific for the protein allergen

A novel hair band is disclosed. The novel hair band comprises a tube having a pre-determined diameter and having a pre-determined length, said tube being constructed with 140 denier lycra wrapped in a 40 denier nylon, said tube being be rolled from both sides so as to form a hair band having two rings. In another embodiment, the invention comprises a system for storing a plurality of hair bands comprising a cylindrical member having a pre-determined outside diameter and having a sufficient length to hold a plurality of hair bands to the exterior of said cylindrical member.

Hair band system with storage and display device

The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.

Isolated nucleic acids encoding an allergen of,III, are disclosed. A cDNA encoding a peptide having a,III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of,III nucleic acid in a sample or for the recombinant production of peptides having an activity of,III. Peptides having an activity of,III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

Growing community of inventors

Belmont, MA, United States of America

Bruce L Rogers