W. R. Grace Co.-conn.

The Medical College of Pennsylvania

Other

The Medical College of Pa

Bruce K Hamilton

George Paul Tuszynski

Jacob Eyal

Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.

Synthetic analogs of thrombospondin and therapeutic use thereof

Methods of use of compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided for promoting or inhibiting thrombospondin-like activity.

Peptides having thrombospondin-like activity and their therapeutic use

Method for using synthetic analogs of thrombospondin for inhibiting

The present invention provides a cell matrix receptor specific for the Cys Ser Val Thr Cys Gly (SEQ ID NO: 1) region of thrombospondin. Also provided are purification, cloning and expression methods. Antibodies directed against the receptor protein are useful in numerous diagnostic, prophylactic and therapeutic areas.

Cys-Ser-Val-Thr-Cys-Gly specific tumor cell adhesion receptor

Compounds and compositions comprising fragments and methods for using synthetic analogs of thrombospondin for promoting or inhbiting thrombospondin-like activity are provided.

Growing community of inventors

Silver Spring, MD, United States of America

Bruce K Hamilton