Takeda Pharmaceutical Company Limited

Agouron Pharmaceuticals, Inc.

Charles River Laboratories, Inc.

Bruce Joseph Elder

Luckner Gerard Ulysse

Zhiyuan Zhang

Paul Isbester

Jeffrey Alan Stafford

Michael Brennan Wallace

Jun Feng

Stephen W Kaldor

Grant Jackson Palmer

Stephen L Gwaltney

Jonathon Stuart Salsbury

Yufeng Hong

Sripathy Venkatraman

Bingidimi Itute Mobele

Paul Kenneth Isbester

Richard S Fornicola

Paul R Brodfuehrer

Jia Liu

Maxwell M Reeve

Yi Li

Philip B Kisanga

Jonathan S Salsbury

Anand Sistla

Paul R Brodfuahrer

ZhiYuan Zhang

Paul K Isbester

Charles B Clifford

Stephen L Ii Gwaltney

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR; Qand Qare each independently selected from the group consisting of CO, SO, SO, and C&#x2550;NR; and each L, X, R, R, and Rare as defined herein.

Dipeptidyl peptidase inhibitors

Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase. 

The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions.

Salts and polymorphs of a VEGF-R inhibitor

The present invention provides a compound of the formula: 

Compounds are provided for use with DPP-IV of the formula: Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

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Wynantskill, NY, United States of America

Bruce Joseph Elder