Eastman-kodak Company

Sterling Winthrop Inc.

Nycomed Imaging As

Bruce J Murray

Michael R Detty

John L Toner

Jerome H Perlstein

David A Hilborn

Timothy Z Hossain

Robert A Snow

Jeanne Ellen Kaeding

Michael Scozzafava

Paul M Borsenberger

Susan A Visser

Ashis Kumar Saha

Bruce E Babb

Michael W Sundberg

Clyde W Shearman

Thomas E Goliber

Chandra R Shah

Richard Philion

A bipolar charge transport material that is useful in electrophotography, said bipolar charge transport material N,N'-bis-�p-(di-p-tolylamino)phenyl!-1,4,5,8-naphthalenetetracarboxylic acid having the structure: ##STR1##

Bipolar charge transport materials useful in electrophotography

The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive group covalently bonded to the complexing agent. The present invention also provides novel complexing agents having the structure A-I, as defined in the specification. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.

Pyridine complexing agents and targeting immunoreagents useful in

A compound of formula ##STR1## where the two R.sup.2 groups, taken together, represent the atoms necessary to complete a macrocyclic ring structure containing at least one heteroatom coordinating site and at least one alkylene group forming part of the ring structure; R.sup.3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; and R.sup.4 represents hydrogen or a protein reactive group, provided that at least one of the R.sup.4 groups is a protein reactive group, and salts, complexes and protein conjugates thereof.

Polycyclic complexing agents

Tripyridyl macrocyclic compounds that are employed in the production of a complexing agent for use in targeting radioactive immunoreagents with the following formula are disclosed: ##STR1## wherein R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group;

Tripyridyl macrocyclic compounds

A targeting radioactive immunoreagent comprising a compound having the structure ##STR1##

Complexing agents and targeting radioactive immunoreagents useful in

Novel chromogenic derivatives of 1,2-bis-(o-aminoaryloxy)ethane-N,N,N',N'-tetraacetic acid are useful for the determination of calcium ions in both solution and dry assays. These compounds comprise a dye moiety which is directly conjugated to the acetic acid substituted-nitrogen atom and which enables the compounds to exhibit maximum absorbance at a wavelength generally greater than 400 nm before complexation. When the compounds are complexed with calcium ions, the absorbance shifts to a shorter wavelength.

Calcium complexing dyes and their use in analytical compositions,

Novel 4H-tellurin compounds are disclosed. The compounds are useful as electron-accepting sensitizers for electron-donating photoconductive-compositions.

Novel 4H-tellurin tellurane electron-accepting sensitizers for

The present invention discloses novel substituted benzotelluropyrones and a novel method for making such compositions. The compositions are useful as intermediates for making benzotelluropyrylium and benzotelluropyrylium diketonate electron dye sensitizers for electron donating photoconductive compositions and elements.

Substituted benzotelluropyrones

The present invention discloses novel mononuclear telluropyrone compositions of matter and a method for making such compositions. The compositions are useful intermediates for making telluropyrylium electron accepting dye sensitizers for photoconductive compositions.

Monocyclic telluropyrones

Novel benzotelluropyrylium diketonate dyes are disclosed. The dyes are useful in improving the performance of electron donating photoconductive compositions and elements. Methods for making the dye sensitizers are also disclosed.

Benzotelluropyrylium diketonate electron accepting dye sensitizers for

Novel telluropyrylium dyes are disclosed. The dyes are useful as electron accepting sensitizers for electron donating photoconductive compositions. Novel methods making the dyes are also disclosed.

Telluropyrylium electron accepting dye sensitizers for electron donating

1,2-oxachalcogenol-1-ium salts are presented. A novel method for making the salts is also presented. The salts are useful in improving the quantum efficiency of organic photoconductive compositions containing organic donor compounds having photoconductive properties.

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Walworth, NY, United States of America

Bruce J Murray