Coulter Electronics, Inc.

Bruce J Hodgins

Guenter Ginsberg

Ivan K Saltz

John A Richardson

Vladimir J Drbal

Ernesto Bello

Rodolfo R Rodriguez

Richard M Grimm

Ted W Britton

A fluid transfer mechanism for rapidly and accurately picking up or aspirating a fluid quantity or aliquot in one position, moving it to a second position and dispensing the aspirated aliquot. The mechanism includes an arm mounted on a high helix shaft on one end and driven up and down the shaft by a first motor and rotated around the shaft by a second motor. The arm includes at a second end a fluid transfer probe which is moved into and out of the fluids to aspirate and dispense the fluids in precise angular locations. The arm may be accelerated and deaccelerated as it is rotated to avoid vibrations and spilling of the fluid from the probe. The probe may include a level sensing structure for sensing when the probe has contacted a fluid surface. The probe also may be coupled to an oscillator to oscillate the probe in a vessel into which the fluid has been dispensed to mix the fluids therein.

Fluid transfer mechanism

A variable stop syringe for automatically selecting, aspirating and dispensing one of a desired plurality of fluid volumes. The variable syringe includes a plurality of stops in an array each of which defines a particular fluid volume. The array selectively is moved to position the desired stop in the fully aspirated position of the syringe plunger. The stop positions are coded and automatically may be read to select the desired syringe stop for the particular volume of fluid desired to be aspirated and dispensed. The completely dispensed and the fully aspirated positions of the plunger, as well as the speed of the plunger operation, may be monitored to ensure that the plunger is operating properly.

Variable stop syringe

A sample and stat feeding system for sequentially supplying a renewable supply of cuvettes with aliquots of sample liquids in a continuous processing mode. The sample liquids are contained in a annular sample tray having a plurality of sample vessels molded into the tray. The sample containers form two or more annular rows on the outer edge of the tray in which routine samples are maintained in an ordered sequence. Emergency samples (stats) and controls (standards) are maintained in separate auxiliary locations or arrays of locations which may be molded or separate cups placed in tray cavities. A sample pick up mechanism has a pick up probe which is rotated to define an arc across at least a substantial portion of the tray and at least one stat location. The tray is rotated to align the sample, stat and control cavities with the arc of the probe. Sample aliquots are picked up and dispensed into the cuvettes in a programed operation sequence, with each sample fluid being related to a particular patient and programed for one or more analytical tests such as measuring the chemical reaction resulting from the addition of one or more reagents from a reagent supply. The program sequencing includes inserting a control aliquot in some of the cuvettes at a predetermined frequency to monitor the accuracy of the machine. When a stat test occurs, the stat is inserted in the tray and the programed sequence is interrupted to load the stat into the reaction vessel. The order of sample locations is not disturbed since the stats and controls are maintained in separate locations. The sample tray preferably will be molded of inexpensive material so it may be thrown away after all sample aliquots have been loaded into respective cuvettes for testing.

Sample and stat feeding system and sample tray

Growing community of inventors

Hialeah, FL, United States of America

Bruce J Hodgins